Pimonidazole

Synonym(s):alpha-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol;;alpha-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol;NSC 380540;PD 126675;;Ro 03-8799;

CAS NO.：70132-50-2
Empirical Formula: C11H18N4O3
Molecular Weight: 254.29
MDL number: MFCD00867974
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-06 15:28:16

What is Pimonidazole?

Description

Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck. This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.

The Uses of Pimonidazole

Pimonidazole is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Biochem/physiol Actions

Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids.

storage

Store at -20°C

Properties of Pimonidazole

Melting point:	110-113°C
Boiling point:	490.5±55.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >20mg/mL
pka	14.06±0.20(Predicted)
form	powder
color	yellow