Pimonidazole
Synonym(s):alpha-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol;;alpha-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol;NSC 380540;PD 126675;;Ro 03-8799;
- CAS NO.:70132-50-2
- Empirical Formula: C11H18N4O3
- Molecular Weight: 254.29
- MDL number: MFCD00867974
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-18 17:01:59
What is Pimonidazole?
Description
Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck. This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
The Uses of Pimonidazole
Pimonidazole is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.
Biochem/physiol Actions
Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids.
storage
Store at -20°C
Properties of Pimonidazole
Melting point: | 110-113°C |
Boiling point: | 490.5±55.0 °C(Predicted) |
Density | 1.39±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >20mg/mL |
pka | 14.06±0.20(Predicted) |
form | powder |
color | yellow |
Safety information for Pimonidazole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Pimonidazole
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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