Pimonidazole
Synonym(s):alpha-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol;;alpha-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol;NSC 380540;PD 126675;;Ro 03-8799;
- CAS NO.：70132-50-2
- Empirical Formula: C11H18N4O3
- Molecular Weight: 254.29
- MDL number: MFCD00867974
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-18 17:01:59
What is Pimonidazole?
Description
Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck. This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
The Uses of Pimonidazole
Pimonidazole is an effective and nontoxic hypoxia detection reagent. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids. It labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.
Biochem/physiol Actions
Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids.
storage
Store at -20°C
Properties of Pimonidazole
| Melting point: | 110-113°C |
| Boiling point: | 490.5±55.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| pka | 14.06±0.20(Predicted) |
| form | powder |
| color | yellow |
Safety information for Pimonidazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Pimonidazole
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3,4-Dibenzyloxybenzaldehyde 4-Hydrazinobenzoic acid 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 3-NITRO-2-METHYL ANILINE 4-IODO BENZOIC ACID 4-HYDROXY BENZYL ALCOHOL 4-(3-chloropropyl)morpholine phenylhydrazine hydrochloride (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 4-methoxy-3,5-dinitropyridine 2-(Cyanocyclohexyl)acetic acid 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride tert-butyl 4- (ureidomethyl)benzylcarbamateRelated products of tetrahydrofuran
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