Pimodivir

CAS NO.：1629869-44-8
Empirical Formula: C20H19F2N5O2
Molecular Weight: 399.39
MDL number: MFCD31382121
Update Date: 2024-11-19 23:02:33

What is Pimodivir?

Description

Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2; K_D = <0.003 μM). It also binds to glycogen synthase kinase 3β (GSK3β; K_i = ^~1.6 μM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC₅₀s = <0.15-2.8 nM in a cell-based assay). It increases the antiviral activity of oseltamivir , zanamivir , and favipiravir (T-705; ) with 50% combination index (CI₅₀) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay. Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.

The Uses of Pimodivir

Pimodivir is an orally bioavailable azaindole inhibitor of influenza PB2.

Properties of Pimodivir

Density	1.501±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO, not in water:100.0(Max Conc. mg/mL);250.38(Max Conc. mM)
form	A solid
pka	4.32±0.40(Predicted)
color	White to light yellow

Safety information for Pimodivir

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.