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HomeProduct name listPIMARIC ACID

PIMARIC ACID

  • CAS NO.:127-27-5
  • Empirical Formula: C20H30O2
  • Molecular Weight: 302.45
  • MDL number: MFCD28369457
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:09
PIMARIC ACID Structural

What is PIMARIC ACID?

Description

Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.

The Uses of PIMARIC ACID

A novel activators of large-conductance Ca2+-activated K+ channel α-subunit.

Definition

ChEBI: (+)-Pimaric acid is a diterpenoid.

Properties of PIMARIC ACID

Melting point: 217-219°
Boiling point: bp18 282°
alpha  D18 +74.7° (c = 0.4 in chloroform); D20 +87.3° (in chloroform)
Density  1.0434 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  Store at -20°C
solubility  DMSO: soluble,Water: soluble
form  Solid
pka 4.68±0.60(Predicted)
color  White to off-white
EPA Substance Registry System Pimaric acid (127-27-5)

Safety information for PIMARIC ACID

Computed Descriptors for PIMARIC ACID

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