Piclamilast
Synonym(s):3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-benzamide;N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide;RP 73401;RP 73-401;RPR 73401
- CAS NO.：144035-83-6
- Empirical Formula: C18H18Cl2N2O3
- Molecular Weight: 381.25
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is Piclamilast?
The Uses of Piclamilast
Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor. Piclamilast may offer therapeutic strategies in respiratory diseases, including asthma and chronic obstructive pulmonary disease. Piclamilast may also provide a treatment option for pre-term infants with bronchopulmonary dysplasia (BPD).
Definition
ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine.
storage
Store at RT
Properties of Piclamilast
| Boiling point: | 447.8±45.0 °C(Predicted) |
| Density | 1.370 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 10.10±0.70(Predicted) |
| form | powder |
| color | white to beige |
Safety information for Piclamilast
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Piclamilast
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![3-(SEC-BUTOXY)PHENYL]METHANAMINE](https://img.chemicalbook.in/CAS/GIF/37806-41-0.gif)
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