Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listPheophorbide A

Pheophorbide A

Synonym(s):(3S,4S,21R)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;Deacetyl-2-vinylbacteriopheophorbide;pheophorbide a;Pheophorbide a5

  • CAS NO.:15664-29-6
  • Empirical Formula: C35H36N4O5
  • Molecular Weight: 592.7
  • MDL number: MFCD00210345
  • EINECS: 239-738-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Pheophorbide A Structural

What is Pheophorbide A?

The Uses of Pheophorbide A

Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.

The Uses of Pheophorbide A

Pheophorbide-a has been used as a photosensitizer:

  • for the photodynamic therapy (PDT) in oral cancer cell lines
  • to test its effect on inducing oxidative stress and death in L. amazonensis
  • to test its effect on the viability of HeLa cells

What are the applications of Application

Pheophorbide a is a chlorophyll-related compound studied for its anti-tumor and anti-cancer activity.

Definition

ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-).

Biochem/physiol Actions

Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.

Enzyme inhibitor

This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.

Properties of Pheophorbide A

Melting point: 191-195 °C
Boiling point: 1019.0±65.0 °C(Predicted)
Density  1.282±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO: soluble0.5mg/mL, clear (warmed)
form  Solid
color  blue, to dark brown to black
Stability: Light Sensitive
EPA Substance Registry System 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6)

Safety information for Pheophorbide A

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Pheophorbide A

Related products of tetrahydrofuran

You may like

  • 15664-29-6 / 28979-78-4 Pheophorbide a 98%
    15664-29-6 / 28979-78-4 Pheophorbide a 98%
    15664-29-6 / 28979-78-4
    View Details
  • Pheophorbide a 95% CAS 15664-29-6
    Pheophorbide a 95% CAS 15664-29-6
    15664-29-6
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.