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HomeProduct name listPheophorbide A

Pheophorbide A

Synonym(s):(3S,4S,21R)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;Deacetyl-2-vinylbacteriopheophorbide;pheophorbide a;Pheophorbide a5

  • CAS NO.:15664-29-6
  • Empirical Formula: C35H36N4O5
  • Molecular Weight: 592.7
  • MDL number: MFCD00210345
  • EINECS: 239-738-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
Pheophorbide A Structural

What is Pheophorbide A?

The Uses of Pheophorbide A

Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.

The Uses of Pheophorbide A

Pheophorbide-a has been used as a photosensitizer:

  • for the photodynamic therapy (PDT) in oral cancer cell lines
  • to test its effect on inducing oxidative stress and death in L. amazonensis
  • to test its effect on the viability of HeLa cells

What are the applications of Application

Pheophorbide a is a chlorophyll-related compound studied for its anti-tumor and anti-cancer activity.

Definition

ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-).

Biochem/physiol Actions

Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.

Enzyme inhibitor

This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.

Properties of Pheophorbide A

Melting point: 191-195 °C
Boiling point: 1019.0±65.0 °C(Predicted)
Density  1.282±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO: soluble0.5mg/mL, clear (warmed)
form  Solid
color  blue, to dark brown to black
Stability: Light Sensitive
EPA Substance Registry System 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6)

Safety information for Pheophorbide A

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Pheophorbide A

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