Pheophorbide A
Synonym(s):(3S,4S,21R)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;Deacetyl-2-vinylbacteriopheophorbide;pheophorbide a;Pheophorbide a5
- CAS NO.:15664-29-6
- Empirical Formula: C35H36N4O5
- Molecular Weight: 592.7
- MDL number: MFCD00210345
- EINECS: 239-738-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is Pheophorbide A?
The Uses of Pheophorbide A
Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.
The Uses of Pheophorbide A
Pheophorbide-a has been used as a photosensitizer:
- for the photodynamic therapy (PDT) in oral cancer cell lines
- to test its effect on inducing oxidative stress and death in L. amazonensis
- to test its effect on the viability of HeLa cells
What are the applications of Application
Pheophorbide a is a chlorophyll-related compound studied for its anti-tumor and anti-cancer activity.
Definition
ChEBI: Pheophorbide a is a pheophorbide. It is a conjugate acid of a pheophorbide a(2-).
Biochem/physiol Actions
Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.
Enzyme inhibitor
This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.
Properties of Pheophorbide A
Melting point: | 191-195 °C |
Boiling point: | 1019.0±65.0 °C(Predicted) |
Density | 1.282±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO: soluble0.5mg/mL, clear (warmed) |
form | Solid |
color | blue, to dark brown to black |
Stability: | Light Sensitive |
EPA Substance Registry System | 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6) |
Safety information for Pheophorbide A
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Pheophorbide A
Pheophorbide A manufacturer
Dr. Silviu Pharmachem Pvt., Ltd.
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