PHENYLGLYOXAL
- CAS NO.:1074-12-0
- Empirical Formula: C8H6O2
- Molecular Weight: 134.13
- MDL number: MFCD00006959
- EINECS: 214-036-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-16 11:06:07
What is PHENYLGLYOXAL?
Chemical properties
white to light yellow powder
What are the applications of Application
Phenylglyoxal monohydrate is a specific reagent for arginine
Definition
ChEBI: Phenylglyoxal is a member of phenylacetaldehydes.
Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 830, 1988 DOI: 10.1021/jo00239a027
Tetrahedron Letters, 27, p. 5139, 1986 DOI: 10.1016/S0040-4039(00)85154-0
Enzyme inhibitor
This commercially available peptide/protein-modifying reagent (FW = 134.13 g/mol; CAS 1074-12-0), occasionally called benzoylformaldehyde, is a mild oxidant that reacts covalently with guanidinium groups at pH ~ 7, consuming two moles of reagent per mole of reactive arginyl residue. Modified guanidinium groups are relatively stable below pH 4; however, the original guanidinium group is slowly regenerated at neutral or alkaline pH. Upon prolonged incubation with phenylglyoxal, a-amino groups may also be modified. See also Glyoxal; 4-Hydroxyphenylglyoxal; etc. Target(s): To date, over 240 enzymes are inhibited by phenylglyoxal
Properties of PHENYLGLYOXAL
Melting point: | ~76 °C |
Boiling point: | 142°C/125mmHg |
Density | 1.133±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
BRN | 1854721 |
InChI | InChI=1S/C8H6O2/c9-6-8(10)7-4-2-1-3-5-7/h1-6H |
CAS DataBase Reference | 1074-12-0(CAS DataBase Reference) |
Safety information for PHENYLGLYOXAL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PHENYLGLYOXAL
InChIKey | OJUGVDODNPJEEC-UHFFFAOYSA-N |
SMILES | C1(=CC=CC=C1)C(=O)C=O |
New Products
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