PHENYL-P-BENZOQUINONE
- CAS NO.：363-03-1
- Empirical Formula: C12H8O2
- Molecular Weight: 184.19
- MDL number: MFCD00001599
- EINECS: 206-654-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is PHENYL-P-BENZOQUINONE?
Chemical properties
Yellow-brown chunks and powder
The Uses of PHENYL-P-BENZOQUINONE
Phenylquinone is used for small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity whichrepresents a potential strategy for anticancer therapy.
Synthesis Reference(s)
Journal of the American Chemical Society, 118, p. 2509, 1996 DOI: 10.1021/ja954009q
Safety Profile
Poison by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
Purification Methods
Crystallise the quinone from heptane, pet ether (b 60-70o), *C6H6 (m 113.5-114.5o) or EtOH (m 112-113o) and sublime it in vacuo. [Carlson & Miller J Am Chem Soc 107 479 1985, Beilstein 7 H 740, 7 III 3764.]
Properties of PHENYL-P-BENZOQUINONE
| Melting point: | 111-115 °C |
| Boiling point: | 278.14°C (rough estimate) |
| Density | 1.1336 (rough estimate) |
| refractive index | 1.6086 (estimate) |
| storage temp. | 2-8°C |
| form | Chunks and Powder |
| color | Yellow-brown |
| EPA Substance Registry System | 2,5-Cyclohexadiene-1,4-dione, 2-phenyl- (363-03-1) |
Safety information for PHENYL-P-BENZOQUINONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PHENYL-P-BENZOQUINONE
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