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HomeProduct name listPhenoxazine

Phenoxazine

  • CAS NO.:135-67-1
  • Empirical Formula: C12H9NO
  • Molecular Weight: 183.21
  • MDL number: MFCD00005014
  • EINECS: 205-210-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-22 17:53:22
Phenoxazine Structural

What is Phenoxazine?

Chemical properties

grey to green-grey fine crystalline powder

The Uses of Phenoxazine

Phenoxazine is a tricyclic 2′deoxycytidine analog that has been used to improve stacking interactions between heterocycles of oligonucleotide/RNA hybrids and to enhance cellular uptake.

Definition

ChEBI: 10H-phenoxazine is a member of the class of phenoxazines that is morpholine which is ortho-fused to two benzene rings at positions 2-3 and 5-6. It has a role as a ferroptosis inhibitor and a radical scavenger.

General Description

Phenoxazine dyes, including several Nile blue analogs, are known to localize selectively in animal tumors.

Purification Methods

Crystallise phenoxazine from EtOH and sublime it in vacuo. If too impure then extract it in a Soxhlet extractor using toluene. Evaporate the solvent and dissolve the residue (ca 100g) in *C6H6 (1L), CARCINOGEN (use an efficient fume cupboard) and chromatograph it through an Al2O3 column (50 x 450 mm) using *C6H6. The eluent (ca 3L) is evaporated to ca 150mL and cooled when ca 103g of phenoxazine m 149-153o is obtained. Sublimation yields platelets m 158-159o. It forms a green picrate m 141.5-142o. [Gilman & Moore J Am Chem Soc 79 3485 1957, Müller et al. J Org Chem 24 37 1959, Beilstein 27 I 223, 27 III/IV 1209.]

Properties of Phenoxazine

Melting point: 156-159 °C (lit.)
Boiling point: 316.88°C (rough estimate)
Density  1.1261 (rough estimate)
RTECS  SP7450000
refractive index  1.5880 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  benzene: freely soluble(lit.)
pka 1.80±0.20(Predicted)
form  Fine Crystalline Powder
color  Gray to green-gray
Water Solubility  Soluble in methanol. Insoluble in water.
Merck  14,7253
BRN  143234
CAS DataBase Reference 135-67-1(CAS DataBase Reference)
NIST Chemistry Reference Phenoxazine(135-67-1)

Safety information for Phenoxazine

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P240:Ground/bond container and receiving equipment.
P241:Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242:Use only non-sparking tools.
P243:Take precautionary measures against static discharge.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378:In case of fire: Use … for extinction.
P405:Store locked up.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for Phenoxazine

InChIKey TZMSYXZUNZXBOL-UHFFFAOYSA-N

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