Phenoxazine
- CAS NO.:135-67-1
- Empirical Formula: C12H9NO
- Molecular Weight: 183.21
- MDL number: MFCD00005014
- EINECS: 205-210-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-12-22 17:53:22
What is Phenoxazine?
Chemical properties
grey to green-grey fine crystalline powder
The Uses of Phenoxazine
Phenoxazine is a tricyclic 2′deoxycytidine analog that has been used to improve stacking interactions between heterocycles of oligonucleotide/RNA hybrids and to enhance cellular uptake.
Definition
ChEBI: 10H-phenoxazine is a member of the class of phenoxazines that is morpholine which is ortho-fused to two benzene rings at positions 2-3 and 5-6. It has a role as a ferroptosis inhibitor and a radical scavenger.
General Description
Phenoxazine dyes, including several Nile blue analogs, are known to localize selectively in animal tumors.
Purification Methods
Crystallise phenoxazine from EtOH and sublime it in vacuo. If too impure then extract it in a Soxhlet extractor using toluene. Evaporate the solvent and dissolve the residue (ca 100g) in *C6H6 (1L), CARCINOGEN (use an efficient fume cupboard) and chromatograph it through an Al2O3 column (50 x 450 mm) using *C6H6. The eluent (ca 3L) is evaporated to ca 150mL and cooled when ca 103g of phenoxazine m 149-153o is obtained. Sublimation yields platelets m 158-159o. It forms a green picrate m 141.5-142o. [Gilman & Moore J Am Chem Soc 79 3485 1957, Müller et al. J Org Chem 24 37 1959, Beilstein 27 I 223, 27 III/IV 1209.]
Properties of Phenoxazine
Melting point: | 156-159 °C (lit.) |
Boiling point: | 316.88°C (rough estimate) |
Density | 1.1261 (rough estimate) |
RTECS | SP7450000 |
refractive index | 1.5880 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | benzene: freely soluble(lit.) |
pka | 1.80±0.20(Predicted) |
form | Fine Crystalline Powder |
color | Gray to green-gray |
Water Solubility | Soluble in methanol. Insoluble in water. |
Merck | 14,7253 |
BRN | 143234 |
CAS DataBase Reference | 135-67-1(CAS DataBase Reference) |
NIST Chemistry Reference | Phenoxazine(135-67-1) |
Safety information for Phenoxazine
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H225:Flammable liquids H336:Specific target organ toxicity,single exposure; Narcotic effects |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for Phenoxazine
InChIKey | TZMSYXZUNZXBOL-UHFFFAOYSA-N |
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