Pheniodol

Originator

Priodax,Schering,US,1943

Definition

ChEBI: Pheniodol sodium is a stilbenoid.

Manufacturing Process

Dextro-β-(4-hydroxyphenyl)-α-phenylpropionic acid (24 g) was dissolved in 630 ml of water containing 8.0 g of sodium hydroxide, and, with good stirring at 25°C, 51 g of iodine and 51 g of potassium iodide dissolved in 240 ml of water was added dropwise over a period of 30 minutes. During this period another 8 g of sodium hydroxide dissolved in 60 ml of water was added in order to keep the reaction mixture alkaline to phenolphthalein. Stirring was continued for 15 minutes longer. The resulting solution was made acid to Congo red with concentrated hydrochloric acid, and about 5 g of sodium bisulfite was added to partially decolorize the resulting slurry. The solid was collected by filtration and washed well with water.
The crude iodinated acid was then dissolved in 500 ml of 95% alcohol, 10 g of dimethylaminoethanol was added, the solution was decolorized with activated charcoal and filtered at 70°C. After keeping the filtrate for several hours at 5°C. the heavy crystalline precipitate which formed was collected by filtration and washed with acetone. The mother liquors were concentrated to 150 ml and cooled to give a second crop which was further purified by recrystallization from 50 ml of 95% alcohol. In this way a total of 36.0 g of dimethylaminoethanol salt of dextro-β-(3,5-diiodo-4-hydroxy)-α- phenylpropionic acid, MP 151° to 153°C, was obtained. The melting point of the dimethylaminoethanol salt of unresolved β-(3,5-diiodo-4-hydroxy)-α- phenylpropionic acid was 142° to 144°C.
The pure dimethylaminoethanol salt was dissolved in 400 ml of 50% acetic acid at 90°C and then cooled to 5°C. The solid which precipitated wascollected by filtration, washed with water, cold 50% acetic acid and finally with low-boiling petroleum ether. After drying in vacuo there was obtained 24 g of hydrated dextro-β-(3,5-diiodo-4-hydroxy)-α-phenylpropionic acid, MP 80° to 85°C.

brand name

Priodax (Schering).

Therapeutic Function

Diagnostic aid (radiopaque medium)

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of Ií.