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HomeProduct name listpheneticillin

pheneticillin

  • CAS NO.:147-55-7
  • Empirical Formula: C17H20N2O5S
  • Molecular Weight: 364.42
  • MDL number: MFCD00869396
  • EINECS: 2056914
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2022-12-21 16:56:50
pheneticillin  Structural

What is pheneticillin ?

Originator

Syncillin, Bristol, US ,1959

The Uses of pheneticillin

Phenethicillin is a penicillin antibiotic medication.

Background

Pheneticillin (or phenethicillin) is a penicillin antibiotic which is approved for use internationally.

Definition

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-phenoxypropanamido group.

Manufacturing Process

Triethylamine (1.5 ml) was added to a cold solution (10°C) of αphenoxypropionic acid (1.66 g, 0.01 mol) in 15 ml of pure dioxane, with stirring and cooling to 5°C to 10°C while isobutyl chloroformate (1.36 g, 0.01 mol) in 5 ml of dioxane was added dropwise. Then the mixture was stirred for ten minutes at 5°C to 8°C. A solution of 6-amino-penicillanic acid (2.16 g, 0.01 mol) in 15 ml of water and 2 ml of triethylamine was then added dropwise while the temperature was maintained below 10°C. The resulting mixture was stirred in the cold for 15 minutes then at room temperature for 30 minutes, diluted with 30 ml of cold water and extracted with ether which was discarded. The cold aqueous solution was then covered with 75 ml of ether and acidified to pH 2 with 5 N H2SO4. After shaking, the ether layer containing the product 6-(α-phenoxypropionamido)penicillanic acid, was dried for ten minutes over anhydrous sodium sulfate and filtered. Addition of 6 ml of dry n-butanol containing 0.373 g/ml of potassium 2-ethylhexanoate precipitated the potassium salt of the product as a colorless oil which crystallized on stirring and scratching and was collected, dried in vacuo and found to weigh 2.75 g, to melt at 217°C to 219°C.

brand name

Chemipen (Bristol-Myers Squibb); Syncillin (Bristol-Myers Squibb) [Name previously used: Phenethicillin.].

Therapeutic Function

Antibacterial

Metabolism

Not Available

Properties of pheneticillin

Boiling point: 673.9±55.0 °C(Predicted)
Density  1.41±0.1 g/cm3(Predicted)
pka 2.44±0.50(Predicted)

Safety information for pheneticillin

Computed Descriptors for pheneticillin

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