PHENAMIL
Synonym(s):3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
- CAS NO.：2038-35-9
- Empirical Formula: C12H12ClN7O
- Molecular Weight: 305.72
- MDL number: MFCD00210211
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is PHENAMIL?
The Uses of PHENAMIL
Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte
What are the applications of Application
Phenamil methanesulfonate salt is an amiloride analog that irreversibly blocks amiloride-sensitive Na+ channels.
Definition
ChEBI: Phenylamil is a member of pyrazines and a member of guanidines.
Enzyme inhibitor
This amiloride derivative (FW = 306.73 g/mol; CAS 2038-35-9), also known as 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine carboxamide, irreversibly inhibits amiloride-sensitive Na+ channels. It is often supplied commercially as the methanesulfonate salt. Na+ channel blockers, such as phenamil and benzamil, are be alsoing explored as a way to counteract the hyperabsorption of NaCl in cystic fibrosis airways. Target(s): diamine oxidase; Na+ channels; and Na+ -driven flagellar motility.
Properties of PHENAMIL
| Melting point: | >181°C (dec.) |
| Density | 1.65±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >15 mg/mL |
| form | solid |
| pka | 8.10±0.46(Predicted) |
| color | yellow |
Safety information for PHENAMIL
Computed Descriptors for PHENAMIL
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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