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HomeProduct name listPHENAMIL METHANESULFONATE

PHENAMIL METHANESULFONATE

  • CAS NO.:1161-94-0
  • Empirical Formula: C13H16ClN7O4S
  • Molecular Weight: 401.8
  • MDL number: MFCD00274070
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-09-03 11:51:57
PHENAMIL METHANESULFONATE Structural

What is PHENAMIL METHANESULFONATE?

Chemical properties

off-white to yellow solid

The Uses of PHENAMIL METHANESULFONATE

Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte

The Uses of PHENAMIL METHANESULFONATE

Phenamil methanesulfonate salt has been used:

  • to stimulate adipocyte differentiation in 3T3 cells
  • to test its effect on lateral flagella expression in Vibrio shilonii
  • in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation

General Description

Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).

Biochem/physiol Actions

Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.

storage

Store at +4°C

Properties of PHENAMIL METHANESULFONATE

storage temp.  2-8°C
solubility  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL
form  solid
color  yellow
CAS DataBase Reference 1161-94-0

Safety information for PHENAMIL METHANESULFONATE

Computed Descriptors for PHENAMIL METHANESULFONATE

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