PHENAMIL METHANESULFONATE
- CAS NO.:1161-94-0
- Empirical Formula: C13H16ClN7O4S
- Molecular Weight: 401.8
- MDL number: MFCD00274070
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-03 11:51:57
What is PHENAMIL METHANESULFONATE?
Chemical properties
off-white to yellow solid
The Uses of PHENAMIL METHANESULFONATE
Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte
The Uses of PHENAMIL METHANESULFONATE
Phenamil methanesulfonate salt has been used:
- to stimulate adipocyte differentiation in 3T3 cells
- to test its effect on lateral flagella expression in Vibrio shilonii
- in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation
General Description
Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).
Biochem/physiol Actions
Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.
storage
Store at +4°C
Properties of PHENAMIL METHANESULFONATE
storage temp. | 2-8°C |
solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL |
form | solid |
color | yellow |
CAS DataBase Reference | 1161-94-0 |
Safety information for PHENAMIL METHANESULFONATE
Computed Descriptors for PHENAMIL METHANESULFONATE
Related products of tetrahydrofuran
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