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HomeProduct name listphanquone

phanquone

  • CAS NO.:84-12-8
  • Empirical Formula: C12H6N2O2
  • Molecular Weight: 210.19
  • MDL number: MFCD00448638
  • EINECS: 201-516-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
phanquone Structural

What is phanquone?

Originator

Phanquinone ,Yick-Vic Chemicals and

Definition

ChEBI: An orthoquinone that is the 5,6-diketo derivative of 4,7-phenanthroline.

Manufacturing Process

2 parts of 6-methoxy-4:7-phenanthroline are mixed with 10 parts by volume of concentrated sulfuric acid and while cooling with a mixture of ice and sodium chloride, with 6 parts by volume of fuming nitric acid (density = 1.51), and the whole is heated for 2 h at 120°C. The reaction solution is poured on to ice, its pH value is adjusted to 7 by means of a 10 N solution of caustic soda, after standing for 2 h the whole is filtered with suction to remove the precipitate which separates, and the latter is washed with hot water. After recrystallising the product from methyl alcohol and drying it at 100°C under 0.1 mm pressure, there are obtained 1.8 parts (i.e. 90 % of the calculated yield) of 4:7-phenanthroline-5:6-quinone in the form of pale yellow crystals melting at 295°C.

Therapeutic Function

Antiamebic

Safety Profile

Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The dione crystallises from MeOH. The mono-oxime forms yellow crystals from MeOH with m 250o(dec), the di-oxime forms yellow crystals from MeOH with m 300o(dec) and the mono-semihydrazone forms yellow crystals from MeOH with m 195o(dec). [Druey & Schmidt Helv Chim Acta 33 1080 1950, Beilstein 24 III/IV 1741.]

Properties of phanquone

Melting point: 295° (dec)
Boiling point: 349.71°C (rough estimate)
Density  1.2785 (rough estimate)
refractive index  1.6000 (estimate)
pka -0.30±0.20(Predicted)
form  Solid
color  Crystals from methanol

Safety information for phanquone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for phanquone

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