PF-6274484
- CAS NO.：1035638-91-5
- Empirical Formula: C18H14ClFN4O2
- Molecular Weight: 372.78
- MDL number: MFCD30182370
- Update Date: 2024-11-01 18:09:03
What is PF-6274484?
Description
PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.
Properties of PF-6274484
| storage temp. | Store at -20°C |
| solubility | DMF: 33 mg/ml; DMSO: 25 mg/ml |
| form | A crystalline solid |
| color | Light yellow to orange |
Safety information for PF-6274484
Computed Descriptors for PF-6274484
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