PF-9366
Synonym(s):7-Chloro-N,N-dimethyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine;PF 9366;PF9366
- CAS NO.：72882-78-1
- Empirical Formula: C20H19ClN4
- Molecular Weight: 350.84
- MDL number: MFCD31630724
- Update Date: 2024-10-28 23:16:16
What is PF-9366?
Description
PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.
The Uses of PF-9366
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.
References
1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785
Properties of PF-9366
| Melting point: | 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 20 mg/ml). |
| form | solid |
| pka | 8.75±0.28(Predicted) |
| color | Beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for PF-9366
Computed Descriptors for PF-9366
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