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HomeProduct name listPF-9366

PF-9366

Synonym(s):7-Chloro-N,N-dimethyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine;PF 9366;PF9366

  • CAS NO.:72882-78-1
  • Empirical Formula: C20H19ClN4
  • Molecular Weight: 350.84
  • MDL number: MFCD31630724
  • Update Date: 2024-11-19 23:02:33
PF-9366 Structural

What is PF-9366?

Description

PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.

The Uses of PF-9366

PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.

References

1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785

Properties of PF-9366

Melting point: 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Density  1.25±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Soluble in DMSO (up to 20 mg/ml).
form  solid
pka 8.75±0.28(Predicted)
color  Beige
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety information for PF-9366

Computed Descriptors for PF-9366

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