PF-6260933

CAS NO.：1811510-56-1
Empirical Formula: C16H13ClN4
Molecular Weight: 296.75
MDL number: MFCD30532622
Update Date: 2024-11-19 20:33:22

What is PF-6260933?

Biological Activity

PF-6260933 is a MAP4K4 inhibitor with IC50 of 3.7 nM and good kinome selectivity.

in vitro

PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.

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in vivo

In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.

Properties of PF-6260933

Boiling point:	483.8±40.0 °C(Predicted)
Density	1.330±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form	A solid
pka	5.04±0.13(Predicted)
color	White to off-white

Safety information for PF-6260933

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.