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HomeProduct name list5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

  • CAS NO.:1332708-14-1
  • Empirical Formula: C26H38N6O2
  • Molecular Weight: 466.62
  • MDL number: MFCD28385599
  • Update Date: 2024-10-31 18:15:48
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Structural

What is 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-?

Biological Activity

PF-4840154 is a potent and selective rat and human TrpA1 channel agonist with EC50 of 97 and 23 nM, respectively. PF-4840154 induces TrpA1-mediated nociceptive behavior in mice.

in vivo

PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse.

Animal Model: Female CD1 mice (25-30g) (In TrpA1+/+ mice)
Dosage: 30 nmol
Administration: Intraplantar (i.pl) injection
Result: Elicited robust licking behavior.

Properties of 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

Density  1.164±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form  A crystalline solid
pka 13.71±0.46(Predicted)
color  White to off-white

Safety information for 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

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