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Petasitenine

Petasitenine Structural

What is Petasitenine?

Description

A pyrrolizidine alkaloid, petasitenine occurs, together with neopetasitenine (q.v.) in Petasites japonicus Maxim. Like the accompanying base, it possesses strong hepatotoxic properties.

Definition

ChEBI: Petasitenine is a spiro-epoxide.

Safety Profile

Questionable carcinogen with experimental carcinogenic data.Mutation data reported. Used as a food and herbal remedy. When heated to decomposition it emits toxic fumes of NOx.

References

Yamada etal., Chem.Lett.,461 (1976)

Properties of Petasitenine

Melting point: 129.5°C
Boiling point: 508.82°C (rough estimate)
Density  1.2977 (rough estimate)
refractive index  1.5180 (estimate)
pka 12.75±0.60(Predicted)
color  Crystals from C6H6/hexane or Me2CO
IARC 3 (Vol. 31, Sup 7) 1987

Safety information for Petasitenine

Computed Descriptors for Petasitenine

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