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HomeProduct name listperimetazine

perimetazine

  • CAS NO.:13093-88-4
  • Empirical Formula: C22H28N2O2S
  • Molecular Weight: 384.541
  • MDL number: MFCD00867994
  • EINECS: 2360093
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
perimetazine Structural

What is perimetazine?

Originator

Leptryl ,Roger Bellon, France,1970

The Uses of perimetazine

Perimethazine, is a novel Antipsychotic drug. It has shown to cause sedation, hypothermia, muscle relaxation, and other signs of central depression in rabbits.

Definition

ChEBI: Perimetazine is a member of phenothiazines.

Manufacturing Process

A solution of 3-methoxy-10-(3-chloro-2-methylpropyl)phenthiazine (9.65 grams) and 4-hydroxypiperidine (6.1 grams) in xylene (10 cc) is heated under reflux for 5 hours. After cooling the mixture is diluted with ether (60 cc) and the basic compounds are extracted by agitation with water (30 cc) and 4 N hydrochloric acid (20 cc). The aqueous acid phase is made alkaline with 4 N sodium hydroxide solution (23 cc) and the liberated base is extracted with ether. The ethereal solution is washed with water (60 cc) and dried over sodium sulfate. Finally the solvent is distilled off on a water-bath.
The solid residue obtained is recrystallized from a mixture (15:85) of benzene and cyclohexane and there is obtained 3-rnethoxy-10-[2-methyl-3-(4hydroxy-1-piperidyl)-propyl]-phenthiazine (5.7 grams) as a white crystalline powder, MP 137°-138°C.

Therapeutic Function

Tranquilizer

Properties of perimetazine

Melting point: 137-138°
Boiling point: 569.1±50.0 °C(Predicted)
Density  1.0944 (rough estimate)
refractive index  1.6000 (estimate)
pka 14.87±0.20(Predicted)

Safety information for perimetazine

Computed Descriptors for perimetazine

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