perimetazine
- CAS NO.:13093-88-4
- Empirical Formula: C22H28N2O2S
- Molecular Weight: 384.541
- MDL number: MFCD00867994
- EINECS: 2360093
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is perimetazine?
Originator
Leptryl ,Roger Bellon, France,1970
The Uses of perimetazine
Perimethazine, is a novel Antipsychotic drug. It has shown to cause sedation, hypothermia, muscle relaxation, and other signs of central depression in rabbits.
Definition
ChEBI: Perimetazine is a member of phenothiazines.
Manufacturing Process
A solution of 3-methoxy-10-(3-chloro-2-methylpropyl)phenthiazine (9.65 grams) and 4-hydroxypiperidine (6.1 grams) in xylene (10 cc) is heated under reflux for 5 hours. After cooling the mixture is diluted with ether (60 cc) and the basic compounds are extracted by agitation with water (30 cc) and 4 N hydrochloric acid (20 cc). The aqueous acid phase is made alkaline with 4 N sodium hydroxide solution (23 cc) and the liberated base is extracted with ether. The ethereal solution is washed with water (60 cc) and dried over sodium sulfate. Finally the solvent is distilled off on a water-bath.
The solid residue obtained is recrystallized from a mixture (15:85) of benzene and cyclohexane and there is obtained 3-rnethoxy-10-[2-methyl-3-(4hydroxy-1-piperidyl)-propyl]-phenthiazine (5.7 grams) as a white crystalline powder, MP 137°-138°C.
Therapeutic Function
Tranquilizer
Properties of perimetazine
Melting point: | 137-138° |
Boiling point: | 569.1±50.0 °C(Predicted) |
Density | 1.0944 (rough estimate) |
refractive index | 1.6000 (estimate) |
pka | 14.87±0.20(Predicted) |
Safety information for perimetazine
Computed Descriptors for perimetazine
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION AMOXICILLIN (AMOXYCILLIN) TRIHYDRATE ACICLOVIR AMLODIPINE SODIUM METHYL PARABEN Methylcobalamin (vitamin B12) SODIUM VALPROATE 5-Fluoro-2-iodo-3-methylaniline Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 3-Bromo-2-hydroxybenzeneacetic acid 5-Iodo-3-methyl-2-nitropyridine 1-(3-Chloro-2-hydroxyphenyl)-2-propanoneRelated products of tetrahydrofuran
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