Perfluorotributylamine
Synonym(s):Fluorinert FC-43;Heptacosafluorotributylamine;Perfluorotributylamine;PFTBA;Tris(nonafluorobutyl)amine
- CAS NO.:311-89-7
- Empirical Formula: C12F27N
- Molecular Weight: 671.09
- MDL number: MFCD00000436
- EINECS: 206-223-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Perfluorotributylamine?
Description
Perfluorotributylamine (PFTBA, also termed FC-43) is a common mass calibrant used in GC-MS systems. It is a dense, moderately high-boiling liquid. It is the main component of Fluosol-43, an artificial blood substitute that has been approved by the US Food and Drug Administration for use in cardiac angioplasty.
PFTBA is also used as an ingredient in some refrigerants. It is persistent in the atmosphere and a powerful greenhouse gas. In 2013, S. A. Mabury at the University of Toronto used IR spectroscopy data to calculate that PFTBA is the strongest global-warming potential of any compound detected in the atmosphere-7100 times greater than that of CO2.
Description
Perfluorotributylamine (PFTBA) is a dense, moderately high-boiling liquid. It is the main component of Fluosol-43, an artificial blood substitute that has been approved by the US Food and Drug Administration for use in cardiac angioplasty. PFTBA is also used as an ingredient in some refrigerants.
But PFTBA has a downside: It is persistent in the atmosphere and a powerful greenhouse gas. In 2013, S. A. Mabury at the University of Toronto used IR spectroscopy data to calculate that PFTBA is the?strongest global-warming potential?of any compound detected in the atmosphere—7100 times greater than that of CO2.
Chemical properties
clear colourless liquid
The Uses of Perfluorotributylamine
Perfluorotributylamine is used in electronic applications viz. liquid burn-in, testing and vapor phase soldering processes. It acts as an indicator fluid to check the leakage and heat transfer fluid for thermal shock testing. It is an active component in fluosol, which is a substitute for artificial blood and fluorinert coolant liquids. Further, it is used as a solvent for computer disc drive lubrication. In addition to this, it is used as a calibration chemical in gas chromatography.
Perfluorotributylamine (PFTBA) is commonly used for the calibration of the mass axes of mass spectrometers, basically in those systems, which use electron ionization (EI). PFTBA may be used as a calibration standard for the gas chromatography-mass spectrometric determination of tramadol in human plasma samples and phthalate esters in water samples.
Definition
ChEBI: Perfluorotributylamine is an organofluorine compound that is tributylamine in which all the hydrogens have been replaced by fluorine atoms. It has a role as a member of greenhouse gas, a solvent and a blood substitute. It derives from a tributylamine.
Preparation
Perfluorotributylamine (PFTBA) is prepared by electrofluorination of tributylamine using hydrogen fluoride as solvent and source of fluorine: N(C4H9)3 + 27 HF → N(C4F9)3+ 27 H2
What are the applications of Application
Perfluorotributylamine (PFTBA) is commonly used in systems that use electron ionisation (EI) for the calibration of mass spectrometer mass spectrometer mass spectrometer axes, and PFTBA can be used as a calibration standard for the determination of tramadol in human plasma samples by gas chromatography-mass spectrometry (GC-MS), and for the determination of phthalate esters in water samples.
Safety
Perfluorotributylamine is belongs to fluorofluids, fluorofluids are generally of very low toxicity, so much that they have been evaluated as synthetic blood.
Precautions
Store in a cool place. Incompatible with powdered metals and alkali metals.
Properties of Perfluorotributylamine
Melting point: | -52 °C |
Boiling point: | 178 °C(lit.) |
Density | 1.883 g/mL at 25 °C(lit.) |
vapor density | 23.3 (vs air) |
vapor pressure | 1.3 mm Hg ( 25 °C) |
refractive index | n |
Flash point: | None |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | Chloroform (Sparingly), Methanol (Slightly) |
form | liquid |
pka | -26.84±0.50(Predicted) |
Specific Gravity | 1.880 |
color | Clear colorless |
Water Solubility | insoluble |
FreezingPoint | -60℃ |
BRN | 1813883 |
Dielectric constant | 1.8999999999999999 |
CAS DataBase Reference | 311-89-7(CAS DataBase Reference) |
NIST Chemistry Reference | Perfluorotributylamine(311-89-7) |
EPA Substance Registry System | 1-Butanamine, 1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(1,1,2,2,3,3,4,4,4-nonafluorobutyl)- (311-89-7) |
Safety information for Perfluorotributylamine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Perfluorotributylamine
InChIKey | VUMYZTYYVRXVJA-UHFFFAOYSA-N |
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