α-Bromo-2,3,4,5,6-pentafluorotoluene
Synonym(s):α-Bromo-2,3,4,5,6-pentafluorotoluene;(Bromomethyl)pentafluorobenzene;2,3,4,5,6-Pentafluorobenzyl bromide;PFB-Br
- CAS NO.:1765-40-8
- Empirical Formula: C7H2BrF5
- Molecular Weight: 260.99
- MDL number: MFCD00000299
- EINECS: 217-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-23 16:18:34
What is α-Bromo-2,3,4,5,6-pentafluorotoluene?
Chemical properties
CLEAR COLOURLESS TO YELLOWISH LIQUID
The Uses of α-Bromo-2,3,4,5,6-pentafluorotoluene
Pentafluorobenzyl bromide (PFB-Br) is an alkylating reagent which can be used to modify hydroxyl groups, carboxyl groups, sulfhydryl groups, and amines.PFB-Br can also be used to measure nitrite and peroxynitrite.It is a versatile reagent.
The Uses of α-Bromo-2,3,4,5,6-pentafluorotoluene
2,3,4,5,6-Pentafluorobenzyl bromide is used as a reagent for derivatization of alcohols, carboxylic acids, sulfonamides for GC and polyfunctional thiols. It is used for the preparation of pentafluorobenzyl esters of organic acids for determination by capillary and GC. It is also used to derivatize N-7-substituted guanine adducts of DNA for determination by GC-electron capture-MS.
The Uses of α-Bromo-2,3,4,5,6-pentafluorotoluene
Learn more in the Product Information
Definition
ChEBI: Pentafluorobenzyl bromide is a member of the class benzyl bromides that is benzyl bromide in which the hydrogens at positions 2, 3, 4, 5 and 6 of the phenyl ring are replaced by fluoro groups. It is a versatile derivatization agent in chromatography and mass spectrometry. It is a member of benzyl bromides and a member of fluorobenzenes.
General Description
Pentafluorobenzyl bromide (PFB-Br) is a derivatization reagent. Excess reagent may be removed by reaction with an aminophenol. It is an alkylation reagent suitable for electron capture detector (ECD) detection. It is also a lachrymator.
Properties of α-Bromo-2,3,4,5,6-pentafluorotoluene
Melting point: | 19-20 °C(lit.) |
Boiling point: | 174-175 °C(lit.) |
Density | 1.728 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 181 °F |
storage temp. | Store below +30°C. |
solubility | Chloroform (Soluble), Ethyl Acetate (Slightly), Methanol (Slightly) |
form | Liquid |
color | Clear colorless to yellow |
Specific Gravity | 1.728 |
Water Solubility | Hydrolyzes in water. |
Sensitive | Lachrymatory |
BRN | 647808 |
CAS DataBase Reference | 1765-40-8(CAS DataBase Reference) |
NIST Chemistry Reference | Benzene, (bromomethyl)pentafluoro-(1765-40-8) |
Safety information for α-Bromo-2,3,4,5,6-pentafluorotoluene
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for α-Bromo-2,3,4,5,6-pentafluorotoluene
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