Pentafluorobenzoyl chloride

Synonym(s):Pentafluorobenzoic acid chloride;Perfluorobenzoyl chloride

CAS NO.：2251-50-5
Empirical Formula: C7ClF5O
Molecular Weight: 230.52
MDL number: MFCD00000657
EINECS: 218-842-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is Pentafluorobenzoyl chloride?

Description

Pentafluorobenzoyl chloride is the acid chloride of pentafluorobenzoic acid. It is a sensitive derivatising reagent for the analysis of amines, amides and phenols by electron capture gas chromatography. It has a role as a chromatographic reagent. It is an acyl chloride and a perfluorinated compound. It derives from a pentafluorobenzoic acid.
2,3,4,5,6-Pentafluorobenzoyl chloride was used for derivatization of 5-androstenediol, testosterone, estradiol , dihydrotestosterone and estrone in a study to determine their serum levels. 2,3,4,5,6-Pentafluorobenzoyl chloride was used to derivatize dimethylamine(DMA) in study to develop a rapid and accurate GC–MS method for determination of DMA in human urine. 2,3,4,5,6-Pentafluorobenzoyl chloride was used in a study to detect the presence of Enterobacter cloacae in cultures of Leuconostoc mesenteroide by gas chromatography/mass spectrometry.

Chemical properties

clear colorless to light yellow liquid

The Uses of Pentafluorobenzoyl chloride

Pentafluorobenzoyl Chloride is a useful analytical reagent in the derivatization amphetamines as well as other primary amines.

The Uses of Pentafluorobenzoyl chloride

Pentafluorobenzoyl chloride can be used for the derivatization of a variety of analytes including biological amines. There is an extensive use for the derivatization of lipids.

The Uses of Pentafluorobenzoyl chloride

A reagent used for deriving primary amines. 2,3,4,5,6-Pentafluorobenzoyl chloride was used for derivatization of 5-androstenediol, testosterone, estradiol , dihydrotestosterone and estrone in a study to determine their serum levels. 2,3,4,5,6-Pentafluorobenzoyl chloride was used to derivative dimethylamine(DMA) in study to develop a rapid and accurate GC-MS method for determination of DMA in human urine. It was used in a study to detect the presence of Enterobacter cloacae in cultures of Leuconostoc mesenteroide by gas chromatography/mass spectrometry.

What are the applications of Application

2,3,4,5,6-Pentafluorobenzoyl chloride is a reagent used for deriving primary amines

Definition

ChEBI: The acid chloride of pentafluorobenzoic acid. It is a sensitive derivatising reagent for the analysis of amines, amides and phenols by electron capture gas chromatography.

Properties of Pentafluorobenzoyl chloride

Boiling point:	158-159 °C(lit.)
Density	1.601 g/mL at 25 °C(lit.)
refractive index	n20/D 1.453(lit.)
Flash point:	None
storage temp.	Store below +30°C.
solubility	soluble in Chloroform
form	Liquid
Specific Gravity	1.601
color	Clear colorless to light yellow
Water Solubility	decomposes
Sensitive	Lachrymatory
BRN	2054397
Stability:	Moisture Sensitive
CAS DataBase Reference	2251-50-5(CAS DataBase Reference)
NIST Chemistry Reference	Pentafluorobenzoyl chloride(2251-50-5)

Safety information for Pentafluorobenzoyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.