PCI 34051
- CAS NO.:950762-95-5
- Empirical Formula: C17H16N2O3
- Molecular Weight: 296.32
- MDL number: MFCD11114393
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is PCI 34051?
The Uses of PCI 34051
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
What are the applications of Application
PCI-34051 is a potent and specific HDAC8 inhibitor
Definition
ChEBI: N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide is an indolecarboxamide.
Biological Activity
pci-34051 is a potent, specific inhibitor of histone deacetylase 8 (hdac8) with greater than 200-fold selectivity over the other hdac isoforms, such as 1, 2, 3, 6 and 10. it induces caspase dependent apoptosis in cell lines derived from t-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. pci-34051 does not cause detectable histone or tubulin acetylation and also does not inhibit growth or induce apoptosis in normal cells such as pbmcs or fibroblasts. although a phospholipase c-gamma1 (plcgamma1) defective line is resistant, cells defective in t-cell receptor signaling are still sensitive to pci-34051 induced apoptosis.
storage
-20°C
Properties of PCI 34051
Density | 1.25 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO |
form | Powder |
pka | 9.16±0.30(Predicted) |
color | White to gray |
Safety information for PCI 34051
Computed Descriptors for PCI 34051
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