parsalmide
- CAS NO.:30653-83-9
- Empirical Formula: C14H18N2O2
- Molecular Weight: 246.3
- MDL number: MFCD00864361
- EINECS: 250-274-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:37
What is parsalmide?
Originator
Parsalmide,Shanghai Lansheng Corporation
Definition
ChEBI: Parsalmide is a member of benzamides.
Manufacturing Process
5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the
presence of sodium hydroxide
5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C.
Therapeutic Function
Muscle relaxant, Antiinflammatory, Analgesic
Properties of parsalmide
Melting point: | 83-85℃ |
Boiling point: | 389.31°C (rough estimate) |
Density | 1.107 |
refractive index | 1.5500 (estimate) |
pka | pKa (aq soln, 20°) 4.6 ±0.03 |
Safety information for parsalmide
Computed Descriptors for parsalmide
Related products of tetrahydrofuran
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