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parsalmide

  • CAS NO.:30653-83-9
  • Empirical Formula: C14H18N2O2
  • Molecular Weight: 246.3
  • MDL number: MFCD00864361
  • EINECS: 250-274-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:37
parsalmide Structural

What is parsalmide?

Originator

Parsalmide,Shanghai Lansheng Corporation

Definition

ChEBI: Parsalmide is a member of benzamides.

Manufacturing Process

5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the presence of sodium hydroxide
5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C.

Therapeutic Function

Muscle relaxant, Antiinflammatory, Analgesic

Properties of parsalmide

Melting point: 83-85℃
Boiling point: 389.31°C (rough estimate)
Density  1.107
refractive index  1.5500 (estimate)
pka pKa (aq soln, 20°) 4.6 ±0.03

Safety information for parsalmide

Computed Descriptors for parsalmide

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