Parecoxib
- CAS NO.:198470-84-7
- Empirical Formula: C19H18N2O4S
- Molecular Weight: 370.42
- MDL number: MFCD08141856
- EINECS: 803-261-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33

What is Parecoxib?
The Uses of Parecoxib
Parecoxib is used in the combination with Telmisartan for the treatment of endometriosis. Parecoxib reduces hippocampal inflammation and improve short-term memory function through the inhibition of COX-2 expression in aged rats after splenectomy.
The Uses of Parecoxib
Anti-inflammatory; analgesic (cyclooxygenase COX-2 inhibitor).
Background
Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005.
Indications
Used for short term perioperative pain control.
Definition
ChEBI: An N-acylsulfonamide resulting from the formal condensation of valdecoxib with propionic acid. It is a prodrug for valdecoxib.
Metabolism
Hepatic. Metabolized primarily via CYP3A4 and 2C9 to valdecoxib and propionic acid.
Properties of Parecoxib
Melting point: | 148.9-151° |
Density | 1.264 |
storage temp. | 2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 5.08±0.10(Predicted) |
form | neat |
form | Solid |
color | White to off-white |
BRN | 8640266 |
Safety information for Parecoxib
Signal word | Warning |
Pictogram(s) |
![]() Health Hazard GHS08 |
GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. |
Computed Descriptors for Parecoxib
New Products
3-Iodophenylacetic acid 3-Pyridineacetonitrile, α-hydroxy- 2-Propanamine, 1-chloro-, hydrochloride (9CI) 3-(hexyloxy)-4-(pyridin-3-yl)-1,2,5-thiadiazole 2-Hexyn-1-ol Dibenzo-18-crown-6 Nickel(II) perchlorate hexahydrate, 98% 4-Bromophenylacetonitrile, 95% 3-Bromo-4-fluoroaniline, 97% Sodium tetraborate decahydrate, 98% Palladium(II) acetate, trimer, Pd 99% 4-Bromo-2-chlorotoluene, 97% N N Dimethylformamide Dimethyl Acetal (Dmf Dma) 2,3-Dichloro Benzoyl Cyanide [Side Chain] Bis(2-Chloroethyl) Amine Hydrochloride L-Glutamic Acid Diethyl Ester Hydrochloride 5-(Difluoromethoxy)-2-Mercaptobenzimidazole 1-Ethyl-3-(3-Dimethylaminopropyl)-Carbodiimide Hydrochloride [EDC Hcl] 1,4-Napthoquinone Bromoiodomethane Sodium Bicarbonate Methylene Dichloride (MDC) Ethyl Acetate Indole-3-Carbinol (I3C)Related products of tetrahydrofuran








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