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HomeProduct name listPamoic acid disodium salt

Pamoic acid disodium salt

Synonym(s):4,4′-Methylenebis(3-hydroxy-2-naphthoic acid);Embonic acid;Sodium pamoate

  • CAS NO.:6640-22-8
  • Empirical Formula: C23H17NaO6
  • Molecular Weight: 412.37
  • MDL number: MFCD00036183
  • EINECS: 229-653-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 21:39:59
Pamoic acid disodium salt Structural

What is Pamoic acid disodium salt?

Chemical properties

pale yellow to yellow powder

The Uses of Pamoic acid disodium salt

Pamoic acid disodium salt, a supposedly inactive component in many formulations of drugs used to modulate release, is a potent agonist of the orphan receptor GPR35. GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR), strongly expressed in the lower intestine and colon, dorsal root ganglia, as well as a variety of immune cells including monocytes and dendritic cells. Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain and cancer.

What are the applications of Application

Pamoic acid disodium salt is an agonist that induces GPR35 internalization and activates ERK1/2

Flammability and Explosibility

Not classified

Biological Activity

Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.

Properties of Pamoic acid disodium salt

Melting point: 300 °C
Density  1.55[at 20℃]
vapor pressure  0.001Pa at 25℃
storage temp.  Desiccate at RT
solubility  insoluble in EtOH; ≥18 mg/mL in H2O; ≥28.6 mg/mL in DMSO
form  solid
color  Pale yellow
Water Solubility  43g/L at 20℃
CAS DataBase Reference 6640-22-8(CAS DataBase Reference)
EPA Substance Registry System 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, disodium salt (6640-22-8)

Safety information for Pamoic acid disodium salt

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Pamoic acid disodium salt

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