Ozagrel hydrochloride
Synonym(s):(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate;OKY-046
- CAS NO.:78712-43-3
- Empirical Formula: C13H13ClN2O2
- Molecular Weight: 264.71
- MDL number: MFCD00911569
- EINECS: 928-470-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:00
What is Ozagrel hydrochloride?
Description
Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM).1?Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2?isomerase (IC50 > 1 mM).1?Inhibits platelet aggregation2?in vitro?and arachidonate-induced arterial contraction?in vivo. Ozagrel HCl protects against arachidonate-induced sudden death in the rabbit3, and alleviates liver injury induced by acetaminophen overdose in mice4.
The Uses of Ozagrel hydrochloride
Ozagrel Hydrochloride is a selective thromboxane A2 synthase inhibitor, which alleviates liver injury induced by acetaminophen overdose in mice.
The Uses of Ozagrel hydrochloride
Antithrombotic;Thromboxane synthase inhibitor
Definition
ChEBI: Ozagrel hydrochloride is an organic molecular entity.
References
1) Hiraku?et al. (1986),?Pharmacological studies on the TXA2?synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046); Jpn. J. Pharmacol.,?41?393 2) Naito?et al. (1983), Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets; Eur. J. Pharmacol.,?91?41 3) Edmonds and Leffer (1984),?Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death; Life Sci.,?35?1763 4) Tomishima?et al. (2013),?Ozagrel hydrochloride, a selective thromboxane A2?synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice; BMC Gastroenterol.,?30?13
Properties of Ozagrel hydrochloride
Melting point: | 214-217° |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | H2O: soluble |
form | solid |
color | white to off-white |
Merck | 14,6980 |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. |
CAS DataBase Reference | 78712-43-3(CAS DataBase Reference) |
Safety information for Ozagrel hydrochloride
Computed Descriptors for Ozagrel hydrochloride
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