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HomeProduct name listOXAZOLAM METHANOL SOLUTION

OXAZOLAM METHANOL SOLUTION

OXAZOLAM METHANOL SOLUTION Structural

What is OXAZOLAM METHANOL SOLUTION?

Originator

Serenal,Sankyo,Japan,1970

The Uses of OXAZOLAM METHANOL SOLUTION

A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).

Definition

ChEBI: Oxazolam is an organic molecular entity and a hemiaminal ether.

Manufacturing Process

To a solution of 12.0 g of 5-chloro-2-chloroacetylaminobenzophenone and 3.2 g of isopropanolamine in 100 ml of ethanol was added 3.3 g of sodium acetate.
The resulting mixture was heated under reflux with stirring for 12 hours. After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off.
The residue was recrystallized from ethanol to give 10.6 g of the desired product melting at 186°C to 188.5°C.

Therapeutic Function

Tranquilizer

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion.An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí and NOx.

Properties of OXAZOLAM METHANOL SOLUTION

Melting point: 187°C
Boiling point: 495.8±45.0 °C(Predicted)
Density  1.2065 (rough estimate)
refractive index  1.5400 (estimate)
Flash point: 11 °C
storage temp.  2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 12.85±0.60(Predicted)
form  A solid

Safety information for OXAZOLAM METHANOL SOLUTION

Computed Descriptors for OXAZOLAM METHANOL SOLUTION

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