OXAZOLAM METHANOL SOLUTION
- CAS NO.:24143-17-7
- Empirical Formula: C18H17ClN2O2
- Molecular Weight: 328.79
- EINECS: 246-032-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:31
What is OXAZOLAM METHANOL SOLUTION?
Originator
Serenal,Sankyo,Japan,1970
The Uses of OXAZOLAM METHANOL SOLUTION
A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).
Definition
ChEBI: Oxazolam is an organic molecular entity and a hemiaminal ether.
Manufacturing Process
To a solution of 12.0 g of 5-chloro-2-chloroacetylaminobenzophenone and 3.2 g of isopropanolamine in 100 ml of ethanol was added 3.3 g of sodium acetate.
The resulting mixture was heated under reflux with stirring for 12 hours. After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off.
The residue was recrystallized from ethanol to give 10.6 g of the desired product melting at 186°C to 188.5°C.
Therapeutic Function
Tranquilizer
Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion.An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí and NOx.
Properties of OXAZOLAM METHANOL SOLUTION
Melting point: | 187°C |
Boiling point: | 495.8±45.0 °C(Predicted) |
Density | 1.2065 (rough estimate) |
refractive index | 1.5400 (estimate) |
Flash point: | 11 °C |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | 12.85±0.60(Predicted) |
form | A solid |
Safety information for OXAZOLAM METHANOL SOLUTION
Computed Descriptors for OXAZOLAM METHANOL SOLUTION
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