Orphenadrine citrate
Synonym(s):β-Dimethylaminoethyl 2-methylbenzhydryl ether citrate salt;o-Methyldiphenhydramine citrate salt;Orphenadrine citrate salt
- CAS NO.:4682-36-4
- Empirical Formula: C24H31NO8
- Molecular Weight: 461.5
- MDL number: MFCD00079197
- EINECS: 225-137-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 13:31:19
What is Orphenadrine citrate?
Chemical properties
White Solid
Originator
Norflex,Riker,US,1959
The Uses of Orphenadrine citrate
Muscle relaxant (skeletal); antihistaminic
The Uses of Orphenadrine citrate
skeletal muscle relaxant, antihistaminic agent
The Uses of Orphenadrine citrate
A histaminergic compound
What are the applications of Application
Orphenadrine Citrate Salt is a histaminergic compound
Definition
ChEBI: A citrate salt which comprises equimolar amounts of orphenadrine and citric acid.
Manufacturing Process
As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.
brand name
Norflex (3M Pharmaceuticals).
Therapeutic Function
Muscle relaxant
General Description
Orphenadrine citrate, N,Ndimethyl-2-(o-methyl-α-phenylbenzyloxy)ethylamine citrate(1:1) (Norflex), introduced in 1957, is closely related todiphenhydramine structurally but has much lower antihistaminicactivity and much higher anticholinergic action.Likewise, it lacks the sedative effects characteristic ofdiphenhydramine. Pharmacological testing indicates that itis not primarily a peripherally acting anticholinergic becauseit has only weak effects on smooth muscle, on the eye,and on secretory glands. It does reduce voluntary musclespasm, however, by a central inhibitory action on cerebralmotor areas, a central effect similar to that of atropine.
Clinical Use
Orphenadrine citrate is used for the symptomatic treatment ofParkinson disease. It relieves rigidity better than it doestremor, and in certain cases, it may accentuate the latter. Thedrug combats mental sluggishness, akinesia, adynamia, andlack of mobility, but this effect seems to diminish rather rapidlywith prolonged use. It is best used as an adjunct to theother agents, such as benztropine, procyclidine, cycrimine,and trihexyphenidyl, in the treatment of paralysis agitans.Orphenadrine citrate is also used as an adjunct to rest, physiotherapy,and other measures to relieve pain of local musclespasm (e.g., nocturnal leg cramps).
The drug has a low incidence of the usual side effectsfor this group, namely, dryness of mouth, nausea, and mildexcitation.
Properties of Orphenadrine citrate
Melting point: | 132-1340C |
storage temp. | Sealed in dry,2-8°C |
solubility | Sparingly soluble in water, slightly soluble in ethanol (96 per cent). |
form | neat |
form | Solid |
color | White to Pale Beige |
CAS DataBase Reference | 4682-36-4(CAS DataBase Reference) |
Safety information for Orphenadrine citrate
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Orphenadrine citrate
InChIKey | ASDBZPGDZBFZAH-UHFFFAOYSA-N |
Abamectin manufacturer
Kores India Limited (Kores Pharmaceuticals And Chemicals)
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