NSC632839hydrochloride
Synonym(s):3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride;4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride;F6
- CAS NO.:157654-67-6
- Empirical Formula: C21H21NO.ClH
- Molecular Weight: 339.864
- MDL number: MFCD09753281
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is NSC632839hydrochloride?
Description
NSC-632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC-632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2?Cell permeable.
The Uses of NSC632839hydrochloride
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 μM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 μM in cells sensitized by E1A, an adenoviral oncogene).
What are the applications of Application
Ubiquitin Isopeptidase Inhibitor II, F6 is a cell-permeable caspase activation and apoptosis inducer
What are the applications of Application
NSC 632839 hydrochloride is an inhibitor of ubiquitin isopeptidase activity
Biological Activity
Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC 50 values are 15.65 and 16.23 μ M in E1A and E1A/C9CN cells respectively).
References
1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235 2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035
Properties of NSC632839hydrochloride
storage temp. | Store at +4°C |
solubility | DMSO: ≥2mg/mL (warmed) |
form | powder |
color | faint yellow to dark yellow |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
Safety information for NSC632839hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NSC632839hydrochloride
New Products
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