NOSCAPINE HYDROCHLORIDE

CAS NO.：912-60-7
Empirical Formula: C22H24ClNO7
Molecular Weight: 449.88
MDL number: MFCD00082546
EINECS: 213-014-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:36

What is NOSCAPINE HYDROCHLORIDE?

Chemical properties

White or almost white, crystalline powder or colourless crystals, hygroscopic.

The Uses of NOSCAPINE HYDROCHLORIDE

Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.

The Uses of NOSCAPINE HYDROCHLORIDE

topical fluoroquinolone antibiotic for acne

The Uses of NOSCAPINE HYDROCHLORIDE

Anti-Tussive

What are the applications of Application

Noscapine hydrochloride is a bradykinin B and tubulin inhibitor

Biological Activity

Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.

Safety Profile

Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.

Properties of NOSCAPINE HYDROCHLORIDE

Melting point:	221-223 °C(lit.)
storage temp.	2-8°C
solubility	Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
form	neat
color	Crystals
Merck	13,6752
EPA Substance Registry System	1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7)

Safety information for NOSCAPINE HYDROCHLORIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H336:Specific target organ toxicity,single exposure; Narcotic effects