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HomeProduct name listNOSCAPINE HYDROCHLORIDE

NOSCAPINE HYDROCHLORIDE

  • CAS NO.:912-60-7
  • Empirical Formula: C22H24ClNO7
  • Molecular Weight: 449.88
  • MDL number: MFCD00082546
  • EINECS: 213-014-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 17:06:36
NOSCAPINE HYDROCHLORIDE Structural

What is NOSCAPINE HYDROCHLORIDE?

Chemical properties

White or almost white, crystalline powder or colourless crystals, hygroscopic.

The Uses of NOSCAPINE HYDROCHLORIDE

Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.

The Uses of NOSCAPINE HYDROCHLORIDE

topical fluoroquinolone antibiotic for acne

The Uses of NOSCAPINE HYDROCHLORIDE

Anti-Tussive

What are the applications of Application

Noscapine hydrochloride is a bradykinin B and tubulin inhibitor

Biological Activity

Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.

Safety Profile

Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.

Properties of NOSCAPINE HYDROCHLORIDE

Melting point: 221-223 °C(lit.)
storage temp.  2-8°C
solubility  Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
form  neat
color  Crystals
Merck  13,6752
EPA Substance Registry System 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7)

Safety information for NOSCAPINE HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H336:Specific target organ toxicity,single exposure; Narcotic effects

Computed Descriptors for NOSCAPINE HYDROCHLORIDE

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