Nonaethylene Glycol Monomethyl Ether

CAS NO.：6048-68-6
Empirical Formula: C19H40O10
Molecular Weight: 428.51
MDL number: MFCD06797148
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is Nonaethylene Glycol Monomethyl Ether ?

Description

m-PEG9-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

Definition

ChEBI: Nonaethylene glycol monomethyl ether is nonaethylene glycol in which one of the hydroxy groups is substituted by methoxy. It is functionally related to a nonaethylene glycol.

in vitro

Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used to synthesize PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Properties of Nonaethylene Glycol Monomethyl Ether

Melting point:	14 °C
Boiling point:	170 °C(Press: 0.01 Torr)
Density	1.10
refractive index	1.4570 to 1.4620
pka	14.36±0.10(Predicted)
form	clear liquid
color	Colorless to Light yellow to Light orange
InChI	InChI=1S/C19H40O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-29-19-18-28-15-14-26-11-10-24-7-6-22-3-2-20/h20H,2-19H2,1H3

Safety information for Nonaethylene Glycol Monomethyl Ether

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.