NOGALAMYCIN
- CAS NO.:1404-15-5
- Empirical Formula: C39H49NO16
- Molecular Weight: 787.8
- MDL number: MFCD00083442
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:59
What is NOGALAMYCIN?
The Uses of NOGALAMYCIN
Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.
The Uses of NOGALAMYCIN
Nogalamycin (cas# 1404-15-5) is a compound useful in organic synthesis.
Definition
ChEBI: Nogalamycin is an anthracycline antibiotic isolated from Streptomyces nogalater. It is a DNA intercalator and exhibits anticancer properties. It has a role as an antineoplastic agent, a cardiotoxic agent, a bacterial metabolite and an intercalator. It is a methyl ester, a polyketide, an anthracycline antibiotic, a tertiary amino compound, a monosaccharide derivative, an organic heterohexacyclic compound and a tetrol.
Biochem/physiol Actions
Anthracyclic antitumor antibiotic.
Safety Profile
Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx.
Properties of NOGALAMYCIN
Melting point: | 195-196° (dec) |
Boiling point: | 658.61°C (rough estimate) |
alpha | D25 +425° (c = 0.11 in CHCl3) |
Density | 1.2095 (rough estimate) |
refractive index | 1.7650 (estimate) |
storage temp. | 2-8°C |
solubility | DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble |
form | A solid |
pka | 7.45 (60% ethanol) |
color | Orange-red solid from MeOH |
Safety information for NOGALAMYCIN
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation H350:Carcinogenicity H360:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for NOGALAMYCIN
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