NOCARDAMINE
- CAS NO.:26605-16-3
- Empirical Formula: C27H48N6O9
- Molecular Weight: 600.7
- MDL number: MFCD08457937
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is NOCARDAMINE?
Description
Nocardamine is a ferrioxamine siderophore that has been found in Streptomyces and has diverse biological activities. It chelates iron in a chrome azurol S assay (IC50 = 9.9 μM). Nocardamine inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron. It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively). Nocardamine also induces morphological changes in BM-N4 insect cells.
The Uses of NOCARDAMINE
Nocardamine is a cyclic siderophore.
What are the applications of Application
Nocardamine is a cyclic siderophore
Definition
ChEBI: A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.
storage
+4°C
References
Normant et al. (2020), Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter; ACS Chem. Biol. 15 2741 Ueki et al. (2009), Nocardamin Production by Streptomyces avermitilis; Actinomycetologica 23 34 Yan et al. (2021), Ferroptosis: mechanisms and links with diseases; Signal Transduct. Target Ther. 6 49 Kalinovskaya et al. (2011), Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity; Res. 166 654 Mahmud et al. (2022), Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809; Molecules 27 2292
Properties of NOCARDAMINE
Melting point: | 192-195° |
Density | 1.162±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (5 mg/ml) |
form | solid |
pka | 8?+-.0.20(Predicted) |
color | Off-white |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for NOCARDAMINE
Computed Descriptors for NOCARDAMINE
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