N,N,N',N'-TETRAMETHYLBENZIDINE

CAS NO.：366-29-0
Empirical Formula: C16H20N2
Molecular Weight: 240.34
MDL number: MFCD00008310
EINECS: 206-676-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:39

What is N,N,N',N'-TETRAMETHYLBENZIDINE?

Chemical properties

solid

Synthesis Reference(s)

Tetrahedron Letters, 13, p. 2193, 1972 DOI: 10.1016/S0040-4039(01)84803-6

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx.

Purification Methods

Crystallise the benzidine from EtOH or pet ether, then from pet ether/*benzene, and sublime it in a vacuum. [Guarr et al. J Am Chem Soc 107 5104 1985.] Dry it in vacuo in a drying pistol, or a vacuum line. It has m 195-196o after sublimation. [Beilstein 13 H 221, 13 I 61, 13 II 97, 13 III 429, 13 IV 368.]

Properties of N,N,N',N'-TETRAMETHYLBENZIDINE

Melting point:	193-195 °C(lit.)
Boiling point:	373.06°C (rough estimate)
Density	1.0485 (rough estimate)
refractive index	1.5519 (estimate)
pka	6.14±0.24(Predicted)
form	Fine Powder
color	Brownish
Stability:	Stable. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.
CAS DataBase Reference	366-29-0(CAS DataBase Reference)
EPA Substance Registry System	[1,1'-Biphenyl]-4,4'-diamine, N,N,N',N'-tetramethyl- (366-29-0)

Safety information for N,N,N',N'-TETRAMETHYLBENZIDINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.