N,N-Dimethylpiperidin-4-amine
- CAS NO.:50533-97-6
- Empirical Formula: C7H16N2
- Molecular Weight: 128.22
- MDL number: MFCD00023144
- EINECS: 256-617-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-16 10:09:33
What is N,N-Dimethylpiperidin-4-amine?
The Uses of N,N-Dimethylpiperidin-4-amine
4-(Dimethylamino)piperidine is having molecular features associated with polyamine modulation of N-methyl-D-aspartate receptors. It is utilized as a mechanism for reducing the effects of alcohol dependence.
Synthesis
1-(tert-Butoxycarbonyl)-4-piperidone (998 mg, 4.75 mmol) in methanol (15 mL) was treated with dimethylamine hydrochloride (800 mg, 9.8 mmol) and sodium cyanoborohydride (270 mg, 4.3 mmol) at rt. After 4 days, concentrated HCl (10 mL) was added and the reaction was reduced in vacuo. The resulting residue was dissolved in H2O (30 mL) and treated with 2M NaOH solution to achieve a pH of 10. The aqueous solution was extracted with methylene chloride (3×20 mL) and the combined organics were dried over Na2SO4 and removed in vacuo. The resulting product is N,N-Dimethylpiperidin-4-amine (169 mg).
storage
Incompatible with air, water, oxidizing agents and heat.
Properties of N,N-Dimethylpiperidin-4-amine
Boiling point: | 187°C |
Density | 1.09g/ml |
Flash point: | 187°C |
refractive index | 1.4760 |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
pka | 10.10±0.10(Predicted) |
color | Clear, colourless |
BRN | 1190 |
CAS DataBase Reference | 50533-97-6(CAS DataBase Reference) |
Safety information for N,N-Dimethylpiperidin-4-amine
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for N,N-Dimethylpiperidin-4-amine
Abamectin manufacturer
GOALSY PHARMA
Sri Neelima Laboratories
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