N,N-Dimethylformamide dimethyl acetal
Synonym(s):N,N-Dimethylformamide dimethyl acetal solution;1,1-Dimethoxy-N,N-dimethylmethylamine;1,1-Dimethoxytrimethylamine;N,N-Dimethyldimethoxymethylamine, DMF-DMA;N,N-Dimethylformamide dimethyl acetal
- CAS NO.：4637-24-5
- Empirical Formula: C5H13NO2
- Molecular Weight: 119.16
- MDL number: MFCD00008482
- EINECS: 225-063-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is N,N-Dimethylformamide dimethyl acetal?
Chemical properties
clear colourless liquid
The Uses of N,N-Dimethylformamide dimethyl acetal
N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.
Definition
ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions
General Description
Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.
Flammability and Explosibility
Highly flammable
Properties of N,N-Dimethylformamide dimethyl acetal
| Melting point: | -85°C |
| Boiling point: | 102-103 °C/720 mmHg (lit.) |
| Density | 0.897 g/mL at 25 °C (lit.) |
| vapor pressure | 34.5hPa at 20℃ |
| refractive index | n |
| Flash point: | 45 °F |
| storage temp. | Store below +30°C. |
| solubility | Miscible with most organic solvents. |
| form | Solid |
| pka | 5.00±0.50(Predicted) |
| color | White to off-white |
| PH | 7 (H2O) |
| explosive limit | 1.3-17.7%(V) |
| Water Solubility | hydrolysis |
| Sensitive | Moisture Sensitive |
| BRN | 506020 |
| Exposure limits | ACGIH: TWA 200 ppm; STEL 250 ppm (Skin) OSHA: TWA 200 ppm(260 mg/m3) NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3) |
| CAS DataBase Reference | 4637-24-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5) |
| EPA Substance Registry System | Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5) |
Safety information for N,N-Dimethylformamide dimethyl acetal
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H332:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for N,N-Dimethylformamide dimethyl acetal
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