N,N-Dimethylformamide dimethyl acetal

Synonym(s):N,N-Dimethylformamide dimethyl acetal solution;1,1-Dimethoxy-N,N-dimethylmethylamine;1,1-Dimethoxytrimethylamine;N,N-Dimethyldimethoxymethylamine, DMF-DMA;N,N-Dimethylformamide dimethyl acetal

CAS NO.：4637-24-5
Empirical Formula: C5H13NO2
Molecular Weight: 119.16
MDL number: MFCD00008482
EINECS: 225-063-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-14 11:55:41

N,N-Dimethylformamide dimethyl acetal Structural

What is N,N-Dimethylformamide dimethyl acetal?

Chemical properties

clear colourless liquid

The Uses of N,N-Dimethylformamide dimethyl acetal

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Definition

ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions

General Description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Flammability and Explosibility

Highly flammable

Properties of N,N-Dimethylformamide dimethyl acetal

Melting point:	-85°C
Boiling point:	102-103 °C/720 mmHg (lit.)
Density	0.897 g/mL at 25 °C (lit.)
vapor pressure	34.5hPa at 20℃
refractive index	n20/D 1.396(lit.)
Flash point:	45 °F
storage temp.	Store below +30°C.
solubility	Miscible with most organic solvents.
form	Solid
pka	5.00±0.50(Predicted)
color	White to off-white
PH	7 (H2O)
explosive limit	1.3-17.7%(V)
Water Solubility	hydrolysis
Sensitive	Moisture Sensitive
BRN	506020
Exposure limits	ACGIH: TWA 200 ppm; STEL 250 ppm (Skin) OSHA: TWA 200 ppm(260 mg/m3) NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)
CAS DataBase Reference	4637-24-5(CAS DataBase Reference)
NIST Chemistry Reference	Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)
EPA Substance Registry System	Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5)

Safety information for N,N-Dimethylformamide dimethyl acetal

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H332:Acute toxicity,inhalation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.