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HomeProduct name listN,N-diisopropyltryptamine

N,N-diisopropyltryptamine

N,N-diisopropyltryptamine Structural

What is N,N-diisopropyltryptamine?

Description

N,N-Diisopropyltryptamine (commonly abbreviated as DiPT) is a synthetic hallucinogenic substance. It is a derivative of the amino acid tryptophan and is closely related to the naturally occurring and widely banned N,N-dimethyltryptamine1 (DMT), the Molecule of the Week for September 17, 2018.
American biochemist Alexander T. Shulgin, the so-called “godfather of psychedelics”, synthesized and experimented with DiPT as early as 1980. His 1997 book TIHKAL2: The Continuation, coauthored with his wife Ann, described their research, including their own experiences, with DiPT and other tryptamine derivatives.
Shulgin published two methods for synthesizing DiPT as its hydrochloride. In the first, he combined indole with oxalyl chloride to form an acyl chloride intermediate, which was treated with diisopropylamine to form indol-3-yl-N,N-diisopropylglyoxylamide. This product was then reduced with lithium aluminum hydride to form DiPT?HCl.
In the second, more direct, synthesis, Shulgin treated tryptamine with isopropyl iodide in the presence of a tertiary amine. The crude free base DiPT was acidified with anhydrous hydrogen chloride to form the HCl salt.
The same article goes on to describe DiPT’s hallucinogenic effects. DiPT is unlike all other psychedelic substances in that it produces primarily auditory effects. At moderate to high doses, it lowers the pitch of perceived sounds. In Shulgin’s experience when he ingested 25 mg:
My wife’s voice is basso, as if she had a cold—my ears with slight pressure as if my tubes were clogged but they aren’t. Radio voices are all low, music out of key. Piano sounds like a bar-room disaster. The telephone ringing sounds partly underwater. In a couple more hours, music pretty much normal again.
DiPT is not a scheduled controlled substance in the United States, although its 5-methoxy derivative (aka “foxy methoxy”) is illegal. Possession of DiPT, however, could possibly be prosecuted under the Federal Analogue Act.
1. DMT continues to be studied as a replacement for side effect–prone ketamine for treating severe depression 2. Abbreviation for “Tryptamines I Have Known and Loved”.

Description

5-Methoxy-N,N-diisopropyltryptamine (5-MeO DiPT) is a psychedelic hallucinogen which is abused worldwide. Known informally as ‘foxy’, this compound potently inhibits the re-uptake of dopamine, serotonin, and norepinephrine (IC50s = 65, 2.2, and 8.2 μM, respectively). DiPT is an uncommonly abused psychedelic drug related to 5-MeO DiPT. Its physiological and toxicological properties have not been extensively reported. This product is intended for forensic and research applications.

The Uses of N,N-diisopropyltryptamine

N,N-diisopropyltryptamine (DiPT) is a psychedelic hallucinogen which is abused worldwide. DiPT is known informally as ‘foxy’, potently inhibits the re-uptake of dopamine, serotonin, and norepinephrine. DiPT is an uncommonly abused psychedelic drug related to 5-MeO DiPT. This product is intended for forensic and research applications.

The Uses of N,N-diisopropyltryptamine

DiPT is a psychedelic hallucinogen which is abused worldwide. DiPT is known informally as ‘foxy’, potently inhibits the re-uptake of dopamine, serotonin, and norepinephrine. DiPT is an uncommonly abused psychedelic drug related to 5-MeO DiPT. This product is intended for forensic and research applications.

Definition

ChEBI: N,N-diisopropyltryptamine is a member of tryptamines.

Properties of N,N-diisopropyltryptamine

Melting point: 46 oc
Boiling point: 376.4±25.0 °C(Predicted)
Density  1.010±0.06 g/cm3(Predicted)
solubility  DMF: 10 mg/ml; DMSO: 14 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.3 mg/ml; Ethanol: 5 mg/ml; Methanol: 1 mg/ml
solubility  ≈14 g/l (est)
appearance white crystalline solid
pka 17.23±0.30(Predicted)
form  A crystalline solid

Safety information for N,N-diisopropyltryptamine

Computed Descriptors for N,N-diisopropyltryptamine

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