N,N'-Diethylthiourea
Synonym(s):1,3-Diethylthiourea;N,N′-Diethylthiourea
- CAS NO.:105-55-5
- Empirical Formula: C5H12N2S
- Molecular Weight: 132.23
- MDL number: MFCD00004925
- EINECS: 203-308-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-29 11:48:30
What is N,N'-Diethylthiourea?
Description
Diethylthiourea, a thiourea derivative, is used mainly as a rubber chemical, particularly in solid neoprene products.
Chemical properties
white to buff-coloured solid
The Uses of N,N'-Diethylthiourea
Diethyl thiourea is the inhibitor of corrosion in metal pick/ing solutions; accelerator for mercaptan-modified chloroprene rubber; antidegradant for natural, nitrile-butadiene, styrene-butadiene, and chloroprene rubbers
The Uses of N,N'-Diethylthiourea
N,N′-Diethylthiourea can be used as a reactant to prepare:
- 3,5-Diethyltetrahydro-4-thioxo-1,3,5-triazine-1(2H)-propanoic acid by condensation reaction with formaldehyde and β-alanine.
- Methyl 3-ethyl-2-(ethylimino)-3,4-dihydro-4-oxo-2H-1,3-thiazine-6-carboxylate by one-pot reaction with dimethyl acetylenedicarboxylate in the presence of triphenylphosphine catalyst.
- 2-(Ethylimino)-3-ethyl-thiazolidin-4-one by cyclization reaction with 2-chloroacetic acid.
- 3-Ethyl-2-(ethylimino)-4-oxo-5-thiazolidineacetamide by condensation reaction with maleimides via Michael-type reaction.
Definition
ChEBI: Thiourea in which each nitogen carries an ethyl substituent.
General Description
Buff solid or white powder.
Air & Water Reactions
N,N'-Diethylthiourea may be sensitive to exposure to air. . Slightly soluble in water.
Reactivity Profile
N,N'-Diethylthiourea is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N'-Diethylthiourea emits toxic fumes.
Fire Hazard
Flash point data are not available for N,N'-Diethylthiourea, but N,N'-Diethylthiourea is probably combustible.
Flammability and Explosibility
Non flammable
Contact allergens
Diethylthiourea, a thiourea derivative, is used mainly as a rubber chemical, particularly in solid neoprene products.
Safety Profile
Poison by ingestion. Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx
Purification Methods
Crystallise it from *benzene. [Beilstein 4 H 118, 4 I 355, 4 II 610, 4 III 220, 4 IV 375.]
Properties of N,N'-Diethylthiourea
Melting point: | 76-78 °C(lit.) |
Boiling point: | 245°C (estimate) |
Density | 1,12 g/cm3 |
vapor pressure | 0.001Pa at 25℃ |
refractive index | 1.5300 (estimate) |
Flash point: | 186 °C |
storage temp. | Store below +30°C. |
solubility | 42g/l |
pka | 14.47±0.70(Predicted) |
form | solid |
color | White to Off-White |
PH | 7 (38g/l, H2O, 20℃) |
Water Solubility | 38 g/L (20 ºC) |
BRN | 773905 |
Stability: | Stable. May be air sensitive. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 105-55-5(CAS DataBase Reference) |
IARC | 3 (Vol. 79) 2001 |
NIST Chemistry Reference | Diethyl-2-thiourea(105-55-5) |
EPA Substance Registry System | N,N'-Diethylthiourea (105-55-5) |
Safety information for N,N'-Diethylthiourea
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H351:Carcinogenicity H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for N,N'-Diethylthiourea
InChIKey | FLVIGYVXZHLUHP-UHFFFAOYSA-N |
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