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HomeProduct name list1,3-Diethyl-1,3-diphenylurea

1,3-Diethyl-1,3-diphenylurea

  • CAS NO.:85-98-3
  • Empirical Formula: C17H20N2O
  • Molecular Weight: 268.35
  • MDL number: MFCD00035794
  • EINECS: 201-645-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-10 16:01:40
1,3-Diethyl-1,3-diphenylurea Structural

What is 1,3-Diethyl-1,3-diphenylurea?

Description

Ethylcentralite (EC), also known as 1,3-Diethyl-1,3-diphenylurea, is a unique compound derived from ethylenediamine, with extensive research focused on its applications in laboratory experiments. The investigation of EC encompasses its potential as an anti-inflammatory, antioxidant, and cognitive enhancer. Additionally, EC shows progression in cancer and neurodegenerative disease research and gene therapy. Furthermore, EC may act as a chelator, effectively binding to metals like iron and copper to prevent their accumulation in the body.

Chemical properties

white crystalline powder

The Uses of 1,3-Diethyl-1,3-diphenylurea

1,3-Diethyl-1,3-diphenylurea is a gunshot residue and a stabilizer for smokeless powder.

The Uses of 1,3-Diethyl-1,3-diphenylurea

As stabilizer of smokeless explosives.

What are the applications of Application

1,3-Diethyl-1,3-diphenylurea is a symmetrical derivative of urea, and a common stabilizer in double-base propellants

General Description

White flakes or white crystalline solid. Peppery odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

N,N'-DIETHYL-N,N'-DIPHENYLUREA (1,3-Diethyl-1,3-diphenylurea) is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). N,N'-DIETHYL-N,N'-DIPHENYLUREA is incompatible with acids and oxidizing agents. N,N'-DIETHYL-N,N'-DIPHENYLUREA reacts violently when severely shocked or exposed to extreme temperatures.

Health Hazard

ACUTE/CHRONIC HAZARDS: N,N'-DIETHYL-N,N'-DIPHENYLUREA may react violently when severely shocked or heated to extreme temperatures.

Fire Hazard

N,N'-DIETHYL-N,N'-DIPHENYLUREA is combustible.

Flammability and Explosibility

Non flammable

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Combustible when exposed to heat or flame. Probably a slight explosion hazard, although it is a component of smokeless explosive mixtures. When heated o decomposition it burns and emits very toxic fumes of NOx. To fight fire, use dry chemical, CO2, spray or mist. An explosion regulator.

Synthesis

The specific synthesis steps of 1,3-Diethyl-1,3-diphenylurea are as follows: A 10 mL Schlenk tube equipped with a magnetic stirring bar was charged with aryl carbamoyl chlorides and KHCO3, and then Pd(PPh3)4 were added. Finally, 1,4-dioxane was added to the mixture via syringe at room temperature under N2. The tube was sealed and put into a preheated oil bath a 100 °C for 48 h. The mixture was cooled to room temperature, quenched with water, and diluted with ethyl acetate. The layers were separated, and the aqueous layer was extracted with 2 × 5 mL of ethyl acetate. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude product was then purified by flash chromatography on silica gel (H), eluting with 30-35% ethyl acetate/petroleum ether.
1,3-Diethyl-1,3-diphenylurea

Properties of 1,3-Diethyl-1,3-diphenylurea

Melting point: 73-75 °C(lit.)
Boiling point: 411.52°C (rough estimate)
Density  1.0208 (rough estimate)
vapor density  9.3 (vs air)
vapor pressure  0Pa at 25℃
refractive index  1.5486 (estimate)
Flash point: 150℃
storage temp.  Sealed in dry,Room Temperature
solubility  acetone: soluble(lit.)
pka 0.63±0.50(Predicted)
form  Solid
color  White to Grey
Water Solubility  40.5mg/L at 20℃
Merck  13,3144
Stability: Shock sensitive.
CAS DataBase Reference 85-98-3(CAS DataBase Reference)
EPA Substance Registry System N,N'-Diethylcarbanilide (85-98-3)

Safety information for 1,3-Diethyl-1,3-diphenylurea

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P273:Avoid release to the environment.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for 1,3-Diethyl-1,3-diphenylurea

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