N,N'-Bis(phenylmethyl)-1,2-ethanediamine
Synonym(s):DBED
- CAS NO.：140-28-3
- Empirical Formula: C16H20N2
- Molecular Weight: 240.34
- MDL number: MFCD00004771
- EINECS: 205-408-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:33
What is N,N'-Bis(phenylmethyl)-1,2-ethanediamine?
Chemical properties
light yellow liquid
The Uses of N,N'-Bis(phenylmethyl)-1,2-ethanediamine
N,N'-Dibenzylethylenediamine is an intermediate of cephalosporin and penicillin.
Definition
ChEBI: Benzathine is a diamine. It is a conjugate base of a benzathine(1+).
Synthesis Reference(s)
The Journal of Organic Chemistry, 55, p. 3209, 1990 DOI: 10.1021/jo00297a042
Safety Profile
Poison by ingestion,intraperitoneal, and parenteral routes. When heated todecomposition it emits toxic vapors of NOx.
Purification Methods
Dissolve DBED in acid, extract with toluene, basify, extract it with Et2O, dry over solid KOH, evaporate and fractionate it in vacuo. The diacetate crystallises from H2O by addition of EtOH and has m 111o (solubility in H2O is ~25%). The dihydrochloride has m 306-308o (from H2O) and the dipicrate has m 212o(dec) (from H2O). [Frost et al., J Am Chem Soc 71 3842 1949, Beilstein 12 H 1067, 12 III 2304.]
Properties of N,N'-Bis(phenylmethyl)-1,2-ethanediamine
| Melting point: | 23-25°C |
| Boiling point: | 195 °C4 mm Hg(lit.) |
| Density | 1.02 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Water (Slightly) |
| form | Solid |
| pka | 9.15±0.19(Predicted) |
| Specific Gravity | 1.025 |
| color | White to Off-White |
| Water Solubility | Slightly soluble in water. |
| FreezingPoint | 21.0 to 25.0 ℃ |
| Sensitive | Air Sensitive |
| Merck | 14,1064 |
| BRN | 786668 |
| CAS DataBase Reference | 140-28-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,2-Ethanediamine, N,N'-bis(phenylmethyl)-(140-28-3) |
| EPA Substance Registry System | 1,2-Ethanediamine, N,N'-bis(phenylmethyl)- (140-28-3) |
Safety information for N,N'-Bis(phenylmethyl)-1,2-ethanediamine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N,N'-Bis(phenylmethyl)-1,2-ethanediamine
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![N,N'-DIBENZYLETHYLENEDIAMINE, [1,2-BIS(BENZYLAMINO)ETHANE]](https://img.chemicalbook.in/StructureFile/ChemBookStructure22/GIF/CB3518333.gif)
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