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HomeProduct name listNitrendipine

Nitrendipine

Synonym(s):1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester;Nitrendipine

  • CAS NO.:39562-70-4
  • Empirical Formula: C18H20N2O6
  • Molecular Weight: 360.36
  • MDL number: MFCD00082255
  • EINECS: 254-513-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-16 15:32:52
Nitrendipine Structural

What is Nitrendipine?

Description

Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged therapeutic effect in comparison to nifedipine makes it useful in the once to twice daily treatment of hypertension.

Chemical properties

Crystalline Solid

Originator

Bayer (W. Germany)

The Uses of Nitrendipine

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

The Uses of Nitrendipine

Antihypertensive;Calcium channel blocker

The Uses of Nitrendipine

Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t e treatment of hypertension.

Indications

For the treatment of mild to moderate hypertension

What are the applications of Application

Nitrendipine is an (L-type) calcium channel protein inhibitor and blocker

Background

Nitrendipine is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.

brand name

Baypress (Bayer);BAYOTENSIN.

General Description

Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.

Biological Activity

L-type calcium channel blocker.

Biochem/physiol Actions

Ca2+ channel blocker; anti-hypertensive.

Pharmacokinetics

Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Metabolism

Not Available

storage

Store at RT

References

1) Meyer et al., (1981), (Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions); Arzneimittelforschung 31 407 2) Stoepel et al., (1981), Pharmacological studies of the antihypertensive effect of nitrendipine; Arzneimittelforschung 31 2056

Properties of Nitrendipine

Melting point: 1580C
Boiling point: 492.4°C (rough estimate)
Density  1.3595 (rough estimate)
refractive index  1.5700 (estimate)
storage temp.  2-8°C
solubility  methanol: 15 mg/mL
form  powder
pka 2.79±0.70(Predicted)
color  yellow to green
Water Solubility  Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.
Stability: Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
CAS DataBase Reference 39562-70-4(CAS DataBase Reference)
NIST Chemistry Reference Nitrendipine(39562-70-4)

Safety information for Nitrendipine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P321:Specific treatment (see … on this label).
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

Computed Descriptors for Nitrendipine

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