Nisoxetine
- CAS NO.:53179-07-0
- Empirical Formula: C17H21NO2
- Molecular Weight: 271.36
- MDL number: MFCD00865443
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is Nisoxetine?
The Uses of Nisoxetine
Antidepressant.
Definition
ChEBI: Nisoxetine is a secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group. It has a role as an antidepressant and an adrenergic uptake inhibitor. It is an aromatic ether and a secondary amino compound.
General Description
Nisoxetine is a SNERI and is an antidepressant. Most activityresides in the β-isomer.
Clinical Use
Nisoxetine was the initial phenoxyphenylpropylamine synthesized in the Lilly research laboratories during the early 1970s from the rearrangement of an oxygen atom in diphenyhydramine, a diphenylmethoxyethylamine, to a phenoxyphenylpropylamine. Nisoxetine was discovered to be a potent and very selective SNRI, with little affinity for other receptors. It underwent clinical studies as an alternative to Lilly's best-selling antidepressant, nortriptyline, but without the adverse effects associated with the tricyclic secondary amines. It was never marketed, however, because of a greater interest in developing its 4-trifluoromethyl analogue, fluoxetine, an SSRI.
Properties of Nisoxetine
Boiling point: | 404.8±40.0 °C(Predicted) |
Density | 1.054±0.06 g/cm3(Predicted) |
pka | 10.16±0.10(Predicted) |
form | Viscous Liquid |
color | Colorless to light yellow |
Safety information for Nisoxetine
Computed Descriptors for Nisoxetine
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