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HomeProduct name listNisoxetine

Nisoxetine

Nisoxetine Structural

What is Nisoxetine?

The Uses of Nisoxetine

Antidepressant.

Definition

ChEBI: Nisoxetine is a secondary amino compound that is N-methyl-3-phenylpropan-1-amine substituted at position 3 by a 2-methoxyphenoxy group. It has a role as an antidepressant and an adrenergic uptake inhibitor. It is an aromatic ether and a secondary amino compound.

General Description

Nisoxetine is a SNERI and is an antidepressant. Most activityresides in the β-isomer.

Clinical Use

Nisoxetine was the initial phenoxyphenylpropylamine synthesized in the Lilly research laboratories during the early 1970s from the rearrangement of an oxygen atom in diphenyhydramine, a diphenylmethoxyethylamine, to a phenoxyphenylpropylamine. Nisoxetine was discovered to be a potent and very selective SNRI, with little affinity for other receptors. It underwent clinical studies as an alternative to Lilly's best-selling antidepressant, nortriptyline, but without the adverse effects associated with the tricyclic secondary amines. It was never marketed, however, because of a greater interest in developing its 4-trifluoromethyl analogue, fluoxetine, an SSRI.

Properties of Nisoxetine

Boiling point: 404.8±40.0 °C(Predicted)
Density  1.054±0.06 g/cm3(Predicted)
pka 10.16±0.10(Predicted)
form  Viscous Liquid
color  Colorless to light yellow

Safety information for Nisoxetine

Computed Descriptors for Nisoxetine

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