Nintedanib esylate
- CAS NO.:656247-18-6
- Empirical Formula: C33H39N5O7S
- Molecular Weight: 649.76
- MDL number: MFCD26142360
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-02 13:34:07
What is Nintedanib esylate?
Description
Nintedanib esylate is a potent, oral triple angiokinase inhibitor developed by Boehringer Ingelheim that targets proangiogenic and pro-fibrotic pathways mediated by the vascular endothelial growth factor receptor, fibroblast growth factor receptor and plateletderived growth factor receptor families, as well as Src and Flt-3 kinases. It was approved for the treatment of idiopathic pulmonary fibrosis (IPF), a condition in which the lungs become progressively scarred over time, by the US FDA in October 2014 and by the EMA in January 2015. The FDA granted nintedanib esylate fast-track, priority review, orphan product, and breakthrough designations. The drug was also approved by the EMA in November 2014 for treatment of non-small cell lung cancer in combination with docetaxel after first-line chemotherapy.
The Uses of Nintedanib esylate
Nintedanib Esylate is the salt form of Nintedanib, which is angiokinase inhibitor and is used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.
What are the applications of Application
Nintedanib esylate is the ethanesulfonate salt form of BIBF1120
Properties of Nintedanib esylate
Melting point: | >233°C (dec.) |
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Yellow solid. |
color | Light Yellow to Yellow |
Safety information for Nintedanib esylate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Nintedanib esylate
Abamectin manufacturer
Basil Drugs AND Pharmaceuticals Pvt Ltd
Equilife Laboratories Pvt Ltd
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