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HomeProduct name listNF449

NF449

Synonym(s):4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl- bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na);NF449 - CAS 389142-38-5 - Calbiochem

NF449 Structural

What is NF449?

The Uses of NF449

NF449 is a known P2X1 receptor antagonist used to regulate the intravascular platelet aggregation commonly seen in systematic thromboembolism.

What are the applications of Application

NF 449 is a selective G-protein antagonist

Biological Activity

Potent purinergic receptor antagonist that displays high selectivity for P2X 1 (IC 50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X 1 , rP2X 1+5 , rP2X 2+3 , rP2X 3 , rP2X 2 and P2X 4 receptors respectively). Provides antithrombotic protection in vivo . Also acts as a G s α -selective antagonist.

Properties of NF449

Melting point: >300°C
Density  1.991±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  H2O: soluble
form  solid
pka -2.03±0.50(Predicted)
color  white
Stability: Hygroscopic

Safety information for NF449

Computed Descriptors for NF449

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