NF 279
Synonym(s):8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na;NF279 - CAS 202983-32-2 - Calbiochem
- CAS NO.:202983-32-2
- Empirical Formula: C49H37N6NaO23S6
- Molecular Weight: 1293.2
- MDL number: MFCD01861187
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:12
What is NF 279?
The Uses of NF 279
NF 279 is a potent and selective P2X1 antagonist.
What are the applications of Application
NF 279 is a highly selective, competitive, and reversible ATP-antagonist of P2X receptor
General Description
A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~1 μM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 μM and >300 μM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 ? rat P2X2 > rat P2X3 ~human P2X7 ? human P2X4. Not degraded by ecto-nucleotidases.
Biological Activity
A potent and selective P2X 1 antagonist (IC 50 = 19 nM). Displays good selectivity over P2X 2 ,(IC 50 = 0.76 μ M), P2X 3 (IC 50 = 1.62 μ M), P2X 4 (IC 50 > 300 μ M), P2Y receptors and ecto-nucleotidases.
Biochem/physiol Actions
Cell permeable: yes
storage
Store at -20°C
Properties of NF 279
storage temp. | Desiccate at -20°C |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
form | White solid |
color | White to off-white |
Water Solubility | Soluble to 25 mM in water |
Stability: | Hygroscopic |
Safety information for NF 279
Computed Descriptors for NF 279
New Products
4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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