NF 023
Synonym(s):8,8′-[Carbonylbis(imino-3,1-phenylene carbonylimino)]bis(1,3,5-naphthalene-trisulfonic acid) hexasodium salt hydrate
- CAS NO.：104869-31-0
- Empirical Formula: C33H20N4Na6O19S6
- Molecular Weight: 1106.86
- MDL number: MFCD01074985
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is NF 023?
The Uses of NF 023
NF 023 is a subtype selective, competitive and reversible P2X1 receptor antagonist.
What are the applications of Application
NF 023 is a subtype selective, competitive and reversible P2X1 receptor antagonist
Biological Activity
A subtype-selective, competitive and reversible P2X 1 receptor antagonist. Displays IC 50 values of 0.21, 28.9, > 50 and > 100 μ M for human P2X 1 , P2X 3 , P2X 2 , and P2X 4 -mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α -subunit of G o/i (EC 50 ~? 300 nM).
Biochem/physiol Actions
NF 023 contains six benzene rings and is a suramin analog. It is a potent, competitive, and selective P2X purinoceptor antagonist that aids in discriminating between P2X receptor subtypes.
storage
Desiccate at RT
Properties of NF 023
| storage temp. | Desiccate at RT |
| solubility | H2O: >20 mg/mL |
| form | crystalline |
| color | white |
| Water Solubility | Soluble to 100 mM in water |
Safety information for NF 023
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NF 023
New Products
4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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