NEUROPEPTIDE S (HUMAN)

CAS NO.：412938-67-1
Empirical Formula: C93H155N31O28S
Molecular Weight: 2187.48
MDL number: MFCD07368606
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:07

What is NEUROPEPTIDE S (HUMAN)?

Biological Activity

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50=9.4 nM). It (TFA) increases motor activity and wakefulness in mice, and has potential for Alzheimer's disease (AD) research.

in vitro

Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC ₅₀ of 6.7 ± 2.4 nM, the binding of [ ^{125I ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K _d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ ^125I I] Y10-NPS, [ ^125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC ₅₀ = 0.42 ± 0.12 nM).}

in vivo

Neuropeptide S human (0.1 nM-1 nM; icv) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice .

Animal Model:	Male C57Bl/6 mice
Dosage:	0.1 nM, 1 nM
Administration:	Intracerebroventricular (icv) injection
Result:	Increased locomotor activity and promoted wakefulness.