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HomeProduct name listNAPHTHOL AS-E PHOSPHATE

NAPHTHOL AS-E PHOSPHATE

Synonym(s):KG-501

  • CAS NO.:18228-17-6
  • Empirical Formula: C17H13ClNO5P
  • Molecular Weight: 377.72
  • MDL number: MFCD00042718
  • EINECS: 242-106-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 21:40:10
NAPHTHOL AS-E PHOSPHATE Structural

What is NAPHTHOL AS-E PHOSPHATE?

Biological Activity

Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

in vitro

Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

in vivo

Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

Properties of NAPHTHOL AS-E PHOSPHATE

Density  1.567±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  DMSO: soluble
form  A crystalline solid
pka 1.04±0.30(Predicted)
color  White to light yellow
BRN  6664478

Safety information for NAPHTHOL AS-E PHOSPHATE

Computed Descriptors for NAPHTHOL AS-E PHOSPHATE

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