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HomeProduct name listNAFRONYL

NAFRONYL

  • CAS NO.:31329-57-4
  • Empirical Formula: C24H33NO3
  • Molecular Weight: 383.53
  • MDL number: MFCD00868290
  • EINECS: 250-572-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
NAFRONYL Structural

What is NAFRONYL?

Originator

Dusodril,Roland,W. Germany,1968

The Uses of NAFRONYL

Nafronyl is a selective inhibitor of serotonin receptors

The Uses of NAFRONYL

Vasodilator.

The Uses of NAFRONYL

Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.

What are the applications of Application

Nafronyl is a vasodilator

Definition

ChEBI: 2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester is a member of naphthalenes.

Manufacturing Process

30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams (0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3. Extraction with ether is carried out after drying over Na2SO4.
Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity = 40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved while being made tepid in 8 cc of acetone. The cooled solution has added thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'- tetrahydrofuryl isobutyrate, obtained according to the process described above and dissolved in 10 cc of acetone. The solution is brought to boiling point for 15 minutes. After cooling to ambient temperature, it is placed in a refrigerator. Crystallization occurs after 2 hours, the crystals which have formed are separated by centrifuging, and after washing in hexane and drying in vacuo 3.5 grams of white crystals are obtained. After being recrystallized three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the product is analytically pure and has a MP = 110° to 111°C (heating stage).

brand name

Praxilene (Lipha, S.A., France).

Therapeutic Function

Vasodilator

World Health Organization (WHO)

Naftidrofuryl is a vasoactive spasmolytic used to treat peripheral vascular disease. It also improves the oxygen utilization in tissues.

Properties of NAFRONYL

Boiling point: bp0.5 190°
Density  d431 1.0465
refractive index  nD29 1.5513
storage temp.  Refrigerator
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly)
form  Oil
pka 9.21±0.25(Predicted)
color  Colourless to Dark Yellow
CAS DataBase Reference 31329-57-4(CAS DataBase Reference)

Safety information for NAFRONYL

Computed Descriptors for NAFRONYL

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